Prediction of Mental Health Complications Following Mild Traumatic Brain Injury.

IF 3.9 2区 医学 Q1 CLINICAL NEUROLOGY
Shuyuan Shi, Ana Mikolić, Joelle LeMoult, Jason Rights, William J Panenka, Noah D Silverberg
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Abstract

Prognostic models can support prevention of mental health complications after mild traumatic brain injury (mTBI). The present study aimed to identify risk factors and develop prognostic model(s) for mental health complications following mTBI. This secondary analysis of data from a randomized controlled trial included 513 adults presenting to emergency departments/urgent care centers. Candidate predictors were demographic, injury-related and health history information collected during medical chart review and eligibility screening, and scores on questionnaires completed at 2 weeks postinjury. The primary outcome was presence/absence of new or worsened major depressive disorder, anxiety disorders, and post-traumatic stress disorder (PTSD), determined with a structured psychodiagnostic interview (Mini International Neuropsychiatric Interview) at 3 and 6 months after mTBI. Logistic regression assessed the prognostic value of 22 pre-, peri-, and early postinjury factors. Least absolute shrinkage and selection operator (LASSO) was used to select predictors in prognostic model development. Younger age, identifying as a person of color, prior mTBI(s), maladaptive illness perceptions, and greater PTSD, and depression and anxiety symptom severity measured at 2 weeks postinjury were significant predictors of new/worsened mental health complications 3-6 months following mTBI. A comprehensive model (with 9 LASSO-selected predictors) showed strong discriminability for predicting mental health complications (optimism-corrected area under the receiver operating characteristic curve [AUC] = 0.80), outperforming a basic model that included only variables commonly collected as part of usual clinical care (optimism-corrected AUC = 0.71). Certain pre-injury and demographic characteristics are associated with increased risk of mental health complications after mTBI. Assessing for early postinjury illness beliefs and psychological symptoms can further improve prognostic accuracy.

轻度创伤性脑损伤后心理健康并发症的预测
预后模型可以支持轻度创伤性脑损伤(mTBI)后心理健康并发症的预防。本研究旨在确定mTBI后精神健康并发症的危险因素并建立预后模型。这项对随机对照试验数据的二次分析包括513名到急诊科/紧急护理中心就诊的成年人。候选预测因子是在病历审查和资格筛选过程中收集的人口统计学、损伤相关和健康史信息,以及损伤后2周完成的问卷得分。主要结局是在mTBI后3个月和6个月通过结构化精神诊断访谈(迷你国际神经精神病学访谈)确定是否存在新的或恶化的重性抑郁症、焦虑症和创伤后应激障碍(PTSD)。Logistic回归评估22个损伤前、损伤中和损伤后早期因素的预后价值。最小绝对收缩和选择算子(LASSO)用于选择预后模型开发中的预测因子。年龄较小、有色人种、既往mTBI、适应性不良疾病认知、更严重的创伤后应激障碍以及损伤后2周测量的抑郁和焦虑症状严重程度是mTBI后3-6个月出现新的/恶化的心理健康并发症的重要预测因素。综合模型(包含9个lasso选择的预测因子)在预测心理健康并发症方面具有很强的可判别性(乐观校正的受试者工作特征曲线下面积[AUC] = 0.80),优于仅包含通常作为临床护理一部分收集的变量的基本模型(乐观校正的AUC = 0.71)。某些损伤前和人口学特征与mTBI后精神健康并发症的风险增加有关。评估早期损伤后疾病信念和心理症状可以进一步提高预后的准确性。
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来源期刊
Journal of neurotrauma
Journal of neurotrauma 医学-临床神经学
CiteScore
9.20
自引率
7.10%
发文量
233
审稿时长
3 months
期刊介绍: Journal of Neurotrauma is the flagship, peer-reviewed publication for reporting on the latest advances in both the clinical and laboratory investigation of traumatic brain and spinal cord injury. The Journal focuses on the basic pathobiology of injury to the central nervous system, while considering preclinical and clinical trials targeted at improving both the early management and long-term care and recovery of traumatically injured patients. This is the essential journal publishing cutting-edge basic and translational research in traumatically injured human and animal studies, with emphasis on neurodegenerative disease research linked to CNS trauma.
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