Treatment of agitation in dementia - a systematic review.

IF 2 Q2 EMERGENCY MEDICINE

International Journal of Emergency Medicine Pub Date : 2025-05-26 DOI:10.1186/s12245-025-00902-7

Misha Choudry, Murdoc Gould, Latha Ganti

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引用次数: 0

Abstract

Dementia, including Alzheimer's disease (AD), affects millions worldwide, leading to cognitive decline, memory loss, and behavioral disturbances. Agitation, a common symptom, poses significant challenges for patients and caregivers. This systematic review evaluates pharmacological and non-pharmacological interventions for managing agitation in dementia. Nine clinical studies were analyzed, encompassing medications like brexpiprazole and non-pharmacological approaches such as music therapy and digital care programs. Pharmacological treatments showed mixed efficacy and safety profiles, with brexpiprazole demonstrating dose-dependent benefits and mirtazapine associating with higher mortality rates. Non-pharmacological interventions exhibited promising results in reducing agitation without adverse effects. The review underscores the importance of personalized care strategies tailored to individual patient needs and preferences to enhance treatment efficacy and quality of life, highlighting the shift toward holistic, individualized care.

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痴呆患者躁动的治疗——一项系统综述。

痴呆症，包括阿尔茨海默病（AD），影响着全世界数百万人，导致认知能力下降、记忆丧失和行为障碍。躁动是一种常见的症状，对患者和护理人员构成了重大挑战。本系统综述评估了治疗痴呆躁动的药理学和非药理学干预措施。九项临床研究进行了分析，包括布雷哌唑等药物以及音乐疗法和数字护理程序等非药物方法。药物治疗的疗效和安全性参差不齐，brexpiprazole显示出剂量依赖的益处，而米氮平与较高的死亡率相关。非药物干预在减少躁动而无不良反应方面显示出有希望的结果。该综述强调了个性化护理策略的重要性，根据患者的个人需求和偏好量身定制，以提高治疗效果和生活质量，强调了向整体、个性化护理的转变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Emergency Medicine EMERGENCY MEDICINE-

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： The aim of the journal is to bring to light the various clinical advancements and research developments attained over the world and thus help the specialty forge ahead. It is directed towards physicians and medical personnel undergoing training or working within the field of Emergency Medicine. Medical students who are interested in pursuing a career in Emergency Medicine will also benefit from the journal. This is particularly useful for trainees in countries where the specialty is still in its infancy. Disciplines covered will include interesting clinical cases, the latest evidence-based practice and research developments in Emergency medicine including emergency pediatrics.