The EZ-ALBI score as a prognostic tool for outcomes after resection of small hepatocellular carcinoma (≤3 cm).

IF 3.9 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Hepatology Research Pub Date : 2025-05-26 DOI:10.1111/hepr.14210

Tomonari Shimagaki, Keishi Sugimachi, Takahiro Tomino, Emi Onishi, Takeo Toshima, Shinji Itoh, Takashi Maeda, Tomoharu Yoshizumi, Masaru Morita

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引用次数: 0

Abstract

Purpose: Liver function is a key prognostic factor in patients with hepatocellular carcinoma (HCC). The albumin-bilirubin (ALBI) score is an objective method to assess liver function severity, but its calculation is complex and challenging to implement in clinical practice. This study evaluated the prognostic utility of the EZ-ALBI score, which uses a simpler and more accessible calculation method, in patients undergoing resection for small HCC (≤3 cm).

Methods: The study included 1161 patients who underwent hepatectomy for small HCC. Data from these patients were analyzed, with 837 patients in dataset A and 324 in dataset B, considering the differences in surgical procedures between facilities.

Results: There was a strong correlation between the ALBI and EZ-ALBI scores across all patients, with a correlation coefficient of 0.974 (p < 0.0001). Comparison between the EZ-ALBI Grade 1 (n = 647) and Grade 2 (n = 514) groups showed that Grade 2 had significantly poorer liver function, shorter operative time, and higher rates of postoperative complications. In dataset A, patients in the EZ-ALBI Grade 2 group had significantly worse overall survival than those in Grade 1 (p < 0.0001). Similar trends were observed in dataset B, where Grade 2 was associated with significantly worse disease-free survival and overall survival. Univariate and multivariate analyses identified the EZ-ALBI score as an independent prognostic factor for OS in both datasets, with Grade 1 patients showing a better prognosis.

Conclusion: The EZ-ALBI score is a valuable prognostic tool for assessing outcomes after resection of small HCC.

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EZ-ALBI评分作为小肝细胞癌（≤3cm）切除后预后的预测工具。

目的：肝功能是影响肝细胞癌（HCC）患者预后的关键因素。白蛋白胆红素（albumin-bilirubin， ALBI）评分是评价肝功能严重程度的一种客观方法，但其计算复杂，在临床实践中难以实现。这项研究评估了EZ-ALBI评分的预后效用，该评分使用了一种更简单、更容易获得的计算方法，用于切除小肝癌（≤3cm）的患者。方法：本研究纳入了1161例因小肝癌行肝切除术的患者。对这些患者的数据进行分析，考虑到不同机构的手术方式差异，数据集A中有837名患者，数据集B中有324名患者。结果：在所有患者中，ALBI和EZ-ALBI评分之间存在很强的相关性，相关系数为0.974 (p)。结论：EZ-ALBI评分是评估小肝癌切除术后预后的有价值的预后工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hepatology Research 医学-胃肠肝病学

CiteScore

8.30

自引率

14.30%

发文量

124

审稿时长

1 months

期刊介绍： Hepatology Research (formerly International Hepatology Communications) is the official journal of the Japan Society of Hepatology, and publishes original articles, reviews and short comunications dealing with hepatology. Reviews or mini-reviews are especially welcomed from those areas within hepatology undergoing rapid changes. Short communications should contain concise definitive information.