Determination, Validation, and Development of Prediction Scores Related to Hypoglycemia Risk Factors Among Ambulatory Type 2 Diabetes Mellitus Patients in Bali, Indonesia.

IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM
Made Krisna Adi Jaya, Fita Rahmawati, Nanang Munif Yasin, Zullies Ikawati
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Abstract

Background: Hypoglycemia is a complication that can disrupt the continuity of therapy for Type 2 Diabetes Mellitus (T2DM) patients. Therefore, ambulatory T2DM patients need supportive treatment to ensure the safety of their medication. Currently, health workers lack a standardized reference for assessing the risk of hypoglycemia in these patients. Therefore, this study aimed to determine, validate, and develop a prediction score of risk factors influencing hypoglycemia in T2DM patients.

Methods: The psychometric properties method was used in this study design, including item development, content validity, criterion validity, and construct validity. During the process of item development, Focus Group Discussions (FGDs) with experts were used. Known predictors were then validated through panelists' content assessment. Risk factors for hypoglycemia from item development and content validation were tested for criterion and construct validation using a case-- control method.

Results: Eight significant predictors caused hypoglycemia, including insulin use, SU use, insulin-- SU combination use, CKD, diabetic neuropathy, uncontrolled blood glucose, >5-year DM duration, and history of severe hypoglycemia, and the total score of risk factors was 24. The categories were defined as follows: scores of 0-8 as low-risk, 9-16 as moderate-risk, and 17-24 as high-risk. There was a positive linear relationship between the total score and risk category (p<0.05; r2: 0.959).

Conclusion: This risk factor and score prediction model can be used by health workers in clinical practice to predict the risk of ambulatory hypoglycemia in T2DM patients because it meets content, criterion, and construct validity.

印度尼西亚巴厘岛2型糖尿病患者低血糖危险因素预测评分的测定、验证和发展
背景:低血糖是一种并发症,可破坏2型糖尿病(T2DM)患者治疗的连续性。因此,非卧床T2DM患者需要支持性治疗,以确保其用药安全。目前,卫生工作者缺乏评估这些患者低血糖风险的标准化参考。因此,本研究旨在确定、验证并建立影响T2DM患者低血糖危险因素的预测评分。方法:本研究设计采用心理测量属性法,包括项目开发、内容效度、标准效度和构念效度。在项目制定过程中,采用了与专家的焦点小组讨论(fgd)。然后通过小组成员的内容评估验证已知的预测因子。采用病例对照法对项目开发和内容验证中的低血糖危险因素进行标准验证和结构验证。结果:胰岛素使用、SU使用、胰岛素- SU联合使用、CKD、糖尿病神经病变、血糖不控制、5年糖尿病病程>、严重低血糖史8项显著预测因素导致低血糖,危险因素总分为24分。分类定义如下:0-8分为低风险,9-16分为中等风险,17-24分为高风险。总分与风险类别呈线性正相关(p2: 0.959)。结论:该危险因素及评分预测模型符合内容、标准及构建效度,可用于临床卫生工作者预测T2DM患者动态低血糖风险。
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来源期刊
Current diabetes reviews
Current diabetes reviews ENDOCRINOLOGY & METABOLISM-
CiteScore
6.30
自引率
0.00%
发文量
158
期刊介绍: Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy. The journal"s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.
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