How Will a Treatable Traits Approach Reshape Clinical Practice in Chronic Cough?

Abstract

Chronic cough, which affects 5%-18% of adults, has traditionally been considered a symptom defined by its duration. However, recent advances in understanding the pathophysiology of chronic cough have prompted the concept that chronic cough may exist as a distinct clinical entity driven by neuronal dysregulation and cough hypersensitivity. This evolving perspective recognizes various treatable traits and clinical characteristics which support the notion of cough as a disease entity and beyond that of a symptom-based classification. Initially developed for asthma and chronic obstructive pulmonary disease, the treatable traits approach has now been extended to chronic cough management, offering a more personalized treatment model. It focuses on identifying modifiable traits that significantly impact patient outcomes. However, challenges remain in implementing this model, including the need for trait validation, biomarker development, staff training, and the integration of new therapies. Despite these challenges, the treatable traits approach provides a promising framework for refining chronic cough management strategies and improving patient care.