Pharmacological interactions between antihypertensive regimens and drugs prescribed in the emergency department.

IF 1 Q4 PHARMACOLOGY & PHARMACY

Annales pharmaceutiques francaises Pub Date : 2025-05-22 DOI:10.1016/j.pharma.2025.05.006

Lilia Edith Luque Esparza, Marco Antonio Osorio García, Delgadillo Guzmán Dealmy, Irais Castillo Maldonado, Citlalli Esmeralda Corvera Aispuro

{"title":"Pharmacological interactions between antihypertensive regimens and drugs prescribed in the emergency department.","authors":"Lilia Edith Luque Esparza, Marco Antonio Osorio García, Delgadillo Guzmán Dealmy, Irais Castillo Maldonado, Citlalli Esmeralda Corvera Aispuro","doi":"10.1016/j.pharma.2025.05.006","DOIUrl":null,"url":null,"abstract":"The risk of drug interactions in patients with HTN is aggravated when prescribing treatments for additional acute pathologies. This can favor adverse reactions to medications or make it difficult to control blood pressure during their stay in the emergency room.Objective: Identify and classify, using CDSS, the IFFs between the antihypertensive treatment regimen and the drugs prescribed in the emergency department.Material and methods: Fifty-three patients with systemic arterial hypertension were treated in the emergency department. Clinical decision support systems are used to identify and classify potential FFs.Results: IFFs were found in 96.2% of hypertensive patients in the emergency department. Those with the highest frequency were of moderate risk. The most frequent mechanism was pharmacodynamic, mainly synergistic by ad-dition.Conclusions: The correlation index between the number of drugs prescribed in the emer-gency room and the presence of IFF shows the need to carry out a scrutiny of the joint pharmaco-logical behavior used in hypertensive patients who attend emergency medical care to rationalize the use of medications reducing the probability of presenting IFF.","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":" ","pages":""},"PeriodicalIF":1.0000,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annales pharmaceutiques francaises","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.pharma.2025.05.006","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}

引用次数: 0

Abstract

The risk of drug interactions in patients with HTN is aggravated when prescribing treatments for additional acute pathologies. This can favor adverse reactions to medications or make it difficult to control blood pressure during their stay in the emergency room.

Objective: Identify and classify, using CDSS, the IFFs between the antihypertensive treatment regimen and the drugs prescribed in the emergency department.

Material and methods: Fifty-three patients with systemic arterial hypertension were treated in the emergency department. Clinical decision support systems are used to identify and classify potential FFs.

Results: IFFs were found in 96.2% of hypertensive patients in the emergency department. Those with the highest frequency were of moderate risk. The most frequent mechanism was pharmacodynamic, mainly synergistic by ad-dition.

Conclusions: The correlation index between the number of drugs prescribed in the emer-gency room and the presence of IFF shows the need to carry out a scrutiny of the joint pharmaco-logical behavior used in hypertensive patients who attend emergency medical care to rationalize the use of medications reducing the probability of presenting IFF.

查看原文本刊更多论文

降压方案与急诊科处方药物之间的药理相互作用。

HTN患者药物相互作用的风险在为其他急性病理开出治疗处方时加剧。这可能有利于药物的不良反应，或使他们在急诊室住院期间难以控制血压。目的：利用CDSS对降压治疗方案与急诊科处方药物间的ifs进行识别和分类。材料与方法：对53例全身性动脉高血压患者进行急诊治疗。临床决策支持系统用于识别和分类潜在的FFs。结果：96.2%的急诊科高血压患者存在ifs。频率最高的是中等风险。最常见的机制是药效学，主要是加药增效。结论：急诊室处方药物数量与IFF存在的相关指数表明，有必要对急诊高血压患者使用的联合药理学行为进行审查，以合理使用药物，降低出现IFF的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Annales pharmaceutiques francaises PHARMACOLOGY & PHARMACY-

CiteScore

1.70

自引率

7.70%

发文量

期刊介绍： This journal proposes a scientific information validated and indexed to be informed about the last research works in all the domains interesting the pharmacy. The original works, general reviews, the focusing, the brief notes, subjected by the best academics and the professionals, propose a synthetic approach of the last progress accomplished in the concerned sectors. The thematic Sessions and the – life of the Academy – resume the communications which, presented in front of the national Academy of pharmacy, are in the heart of the current events.