Real-World Effectiveness and Safety of Mepolizumab in Severe Eosinophilic Asthma: Insights From the Korean Severe Asthma Registry (KoSAR).

IF 4.1 2区 医学 Q2 ALLERGY
So-Young Park, Daegeun Lee, Joo-Hee Kim, Youngsoo Lee, Ga-Young Ban, Da Woon Sim, Jae-Woo Kwon, So Ri Kim, Woo-Jung Song, Heung-Woo Park, Yoon-Seok Chang, Young-Il Koh, Byung-Jae Lee, Hae-Sim Park, You Sook Cho, Sang-Heon Kim
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Abstract

Mepolizumab, an interleukin-5 antagonist, is globally recognized for its efficacy in randomized controlled trials for the treatment of severe eosinophilic asthma. The present study explored its real-world effectiveness and safety in a Korean cohort, filling a critical gap in current research. This multi-center retrospective study used data from the Korean Severe Asthma Registry, involving 67 patients treated with mepolizumab for uncontrolled severe asthma between September 2017 and July 2022. We assessed the effects of treatment on acute exacerbations, oral corticosteroid (OCS) maintenance dose, lung function, and quality of life. The notable findings included a marked reduction in the proportion of patients experiencing acute exacerbations, with 73.0% of patients reporting no exacerbations during the 6-month treatment period. At baseline, 31.8% of patients had reported no exacerbations over the prior 12 months. The OCS maintenance doses also decreased substantially, with only 3.2% of patients requiring OCS after 6 months. Additionally, there was an improvement in lung function. No severe adverse reactions were reported in this study, highlighting the safety of mepolizumab. This study confirmed that mepolizumab reduced exacerbations and OCS use, with additional improvements seen in asthma control, lung function, and patient-reported quality of life. These real-world findings support broader applications and reinforce the need for further research to optimize treatment strategies. Despite certain limitations, such as the small sample size and retrospective design, this study significantly contributes to the understanding of the real-world efficacy and safety of mepolizumab.

Mepolizumab在严重嗜酸性粒细胞哮喘中的实际有效性和安全性:来自韩国严重哮喘登记(KoSAR)的见解
Mepolizumab是一种白细胞介素-5拮抗剂,在治疗严重嗜酸性粒细胞性哮喘的随机对照试验中具有全球公认的疗效。本研究在韩国队列中探索了其现实世界的有效性和安全性,填补了当前研究中的一个关键空白。这项多中心回顾性研究使用了韩国严重哮喘登记处的数据,包括2017年9月至2022年7月期间接受mepolizumab治疗的67例未控制的严重哮喘患者。我们评估了治疗对急性加重、口服皮质类固醇(OCS)维持剂量、肺功能和生活质量的影响。值得注意的发现包括出现急性加重的患者比例显著降低,73.0%的患者报告在6个月的治疗期间没有加重。在基线时,31.8%的患者报告在过去12个月内没有恶化。OCS维持剂量也大幅下降,6个月后只有3.2%的患者需要OCS。此外,肺功能也有所改善。本研究未报告严重不良反应,强调了mepolizumab的安全性。该研究证实,mepolizumab减少了急性发作和OCS的使用,在哮喘控制、肺功能和患者报告的生活质量方面也有进一步的改善。这些现实世界的发现支持了更广泛的应用,并加强了进一步研究以优化治疗策略的必要性。尽管存在一定的局限性,例如样本量小和回顾性设计,但本研究显著有助于了解mepolizumab的实际疗效和安全性。
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来源期刊
CiteScore
6.10
自引率
6.80%
发文量
53
审稿时长
>12 weeks
期刊介绍: The journal features cutting-edge original research, brief communications, and state-of-the-art reviews in the specialties of allergy, asthma, and immunology, including clinical and experimental studies and instructive case reports. Contemporary reviews summarize information on topics for researchers and physicians in the fields of allergy and immunology. As of January 2017, AAIR do not accept case reports. However, if it is a clinically important case, authors can submit it in the form of letter to the Editor. Editorials and letters to the Editor explore controversial issues and encourage further discussion among physicians dealing with allergy, immunology, pediatric respirology, and related medical fields. AAIR also features topics in practice and management and recent advances in equipment and techniques for clinicians concerned with clinical manifestations of allergies and pediatric respiratory diseases.
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