Peripheral Blood Flow Cytometry-based Definition of Plasma Cell Leukemia

IF 13.4 1区医学 Q1 HEMATOLOGY

Leukemia Pub Date : 2025-05-26 DOI:10.1038/s41375-025-02653-z

Arwa Bohra, Rafla Hassan, Saurabh Zanwar, Dragan Jevremovic, Horatiu Olteanu, Wilson I. Gonsalves, Gregory Otteson, Pedro Horna, S. Vincent Rajkumar, Shaji Kumar

引用次数: 0

Abstract

TO THE EDITOR:

Plasma cell leukemia (PCL), an aggressive form of MM, is defined by the International Myeloma Working Group (IMWG) as the presence of ≥5% circulating plasma cells (CPCs) in the peripheral blood [1]. Moreover, PCL cases are frequently enriched in the translocation t(11;14), which presents with a lympho-plasmacytoid morphology, complicating detection through standard morphological examination [2].

Abstract Image

查看原文本刊更多论文

外周血流式细胞术对浆细胞白血病的定义

浆细胞白血病（PCL）是一种侵袭性MM，被国际骨髓瘤工作组（IMWG）定义为外周血中存在≥5%的循环浆细胞（cpc）。此外，PCL病例经常富含易位t(11;14)，其表现为淋巴浆细胞样形态，使标准形态学检查[2]的检测变得复杂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Leukemia 医学-血液学

CiteScore

18.10

自引率

3.50%

发文量

270

审稿时长

3-6 weeks

期刊介绍： Title: Leukemia Journal Overview: Publishes high-quality, peer-reviewed research Covers all aspects of research and treatment of leukemia and allied diseases Includes studies of normal hemopoiesis due to comparative relevance Topics of Interest: Oncogenes Growth factors Stem cells Leukemia genomics Cell cycle Signal transduction Molecular targets for therapy And more Content Types: Original research articles Reviews Letters Correspondence Comments elaborating on significant advances and covering topical issues