A Reductive Ugi Reaction with Carboxylic Acids Replacing Aldehydes.

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-05-26 DOI:10.1021/acs.orglett.5c01785

Xiaohong Li,Jinxi Huang,Huanfeng Jiang,Liangbin Huang

引用次数: 0

Abstract

Here, we report a Ti(IV)-catalyzed reductive Ugi reaction in which two distinct carboxylic acids replace aldehyde and carboxylic acid components. The Ti(IV) catalyst exhibits dual roles: promoting the deoxygenative imination of carboxylic acids through its oxophilicity and acting as a Lewis acid to activate imine intermediates for the the Ugi reaction. The addition of methanol quenches excess hydrosilane, ensuring an efficient tandem process. This one-pot tandem reaction expands the carboxylic acid utility in MCRs, offering a platform for drug discovery, functional materials, and natural product synthesis.

查看原文本刊更多论文

羧酸取代醛的还原性Ugi反应。

在这里，我们报道了Ti（IV）催化的还原Ugi反应，其中两种不同的羧酸取代醛和羧酸成分。Ti（IV）催化剂具有双重作用：通过其亲氧性促进羧酸的脱氧亚胺反应，并作为Lewis酸激活亚胺中间体进行Ugi反应。添加甲醇淬灭多余的氢硅烷，确保高效的串联工艺。这种一锅串联反应扩展了羧酸在mcr中的应用，为药物发现、功能材料和天然产物合成提供了一个平台。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.