A 90 g/day low-carbohydrate diet improved glycemic control without decreasing frailty in older patients with type 2 diabetes: A secondary analysis of a randomized controlled trial.

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-05-24 DOI:10.1111/jdi.70083

Yu-Ting Wang, Chin-Ying Chen, Wei-Sheng Huang, Hui-Chuen Chen, Long-Teng Lee, Chyi-Feng Jan, Hsien-Liang Huang, Jaw-Shiun Tsai

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Abstract

Aims: This study explored the glycemic control and Fried frailty criteria of a 90 g/day low-carbohydrate diet (LCD) in older patients with type 2 diabetes over 18 months.

Methods: Forty-four older patients with type 2 diabetes and HbA1c ≥ 7.5% (58 mmol/mol) at the outpatient clinics were randomly assigned to a 90 g/day LCD or traditional diabetic diet (TDD). The analysis was performed using an intention-to-treat analysis.

Results: A total of 42 (95.5%) patients completed the trial. The 18-month mean change from baseline was statistically significant for 2-h glucose (-100.0 ± 57.7 vs -18.6 ± 86.2 mg/dL) and waist circumference (-6.3 ± 7.9 vs -1.7 ± 4.7 cm) between the LCD and TDD groups (P < 0.05). The 18-month mean change from baseline was not significantly different in HbA1c (-1.55 ± 1.0 vs -0.97 ± 1.2; P = 0.097). After intervention, the proportions of robust, pre-frailty, and frailty in the TDD and LCD groups were 20.0% vs 13.6%, 75.0% vs 86.4%, and 5.0% vs 0.0%, respectively (P > 0.05).

Conclusions: A 90 g/d LCD reflected improved glycemic control with significantly lower waist circumference without decreasing frailty in older patients with type 2 diabetes.

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90克/天的低碳水化合物饮食改善了老年2型糖尿病患者的血糖控制，但没有减少虚弱：一项随机对照试验的二次分析。

目的：本研究探讨90 g/d低碳水化合物饮食（LCD）对老年2型糖尿病患者18个月以上的血糖控制和Fried衰弱标准。方法：选取44例HbA1c≥7.5% （58 mmol/mol）的老年2型糖尿病门诊患者，随机分为90g /d LCD组和传统糖尿病饮食组（TDD）。使用意向治疗分析进行分析。结果：共有42例（95.5%）患者完成了试验。LCD组和TDD组2小时血糖（-100.0±57.7 vs -18.6±86.2 mg/dL）和腰围（-6.3±7.9 vs -1.7±4.7 cm）与基线相比18个月的平均变化具有统计学意义（P < 0.05）。结论：90g /d的LCD可以改善老年2型糖尿病患者的血糖控制，显著降低腰围，但不减少虚弱。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Diabetes Investigation Medicine-Internal Medicine

自引率

9.40%

发文量

218

期刊介绍： Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).