Numerical Investigation of Hemodynamic Factors in Cellular Blood Flow: Insights From Curved Microvessels

IF 1.9 4区医学 Q3 HEMATOLOGY

Microcirculation Pub Date : 2025-05-26 DOI:10.1111/micc.70013

Mojtaba Amir Aslan Pour, Wenbin Mao

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引用次数: 0

Abstract

Objective

This study investigates the effects of hemodynamic factors on blood cell suspension flows and their properties in curved microvessels. A parametric study is employed to compare these properties between curved and straight vessels.

Methods

A 3D fluid solver coupled with a cell membrane modeling framework via the immersed boundary method was used to simulate cell-resolved blood flow in straight and curved vessels featuring a 90° bend with moderate curvature.

Results

Blood flow in curved vessels shows lower and higher shear rates in the inner and outer bulk regions, respectively, compared to straight vessels. Asymmetry in hematocrit profiles is linked to less dense suspensions, smaller diameters, and higher Capillary numbers, while the maximum velocity location remains consistent with straight vessels. At physiological shear rates, moderate curvatures, and large diameters, curvature has minimal impact on apparent viscosity. However, diffusivity is elevated at the center of curved vessels compared to straight ones.

Conclusions

This study reveals new insights into blood suspension flows in curved microvessels with a 90° bend, highlighting key differences from straight vessels under certain hemodynamic conditions. These findings lay the groundwork for future research on realistic microvessel geometries and their implications.

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细胞血流中血流动力学因素的数值研究：来自弯曲微血管的见解

目的研究血流动力学因素对弯曲微血管中血细胞悬浮流动及其性质的影响。采用参数研究来比较弯曲和直血管的这些特性。方法采用浸入边界法的三维流体求解器和细胞膜建模框架，分别模拟90°弯曲的直血管和弯曲血管的细胞解析血流。结果与直血管相比，弯曲血管内、外体积区血流剪切率分别较低、较高。红细胞压积分布的不对称性与悬浮液密度较低、直径较小和毛细血管数量较多有关，而最大流速位置与直血管保持一致。在生理剪切速率、中等曲率和大直径下，曲率对表观粘度的影响最小。然而，与直血管相比，弯曲血管中心的扩散率升高。本研究揭示了90°弯曲微血管血液悬浮液流动的新见解，突出了在某些血流动力学条件下与直血管的关键差异。这些发现为未来研究真实微血管几何形状及其意义奠定了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microcirculation 医学-外周血管病

CiteScore

5.00

自引率

4.20%

发文量

审稿时长

6-12 weeks

期刊介绍： The journal features original contributions that are the result of investigations contributing significant new information relating to the vascular and lymphatic microcirculation addressed at the intact animal, organ, cellular, or molecular level. Papers describe applications of the methods of physiology, biophysics, bioengineering, genetics, cell biology, biochemistry, and molecular biology to problems in microcirculation. Microcirculation also publishes state-of-the-art reviews that address frontier areas or new advances in technology in the fields of microcirculatory disease and function. Specific areas of interest include: Angiogenesis, growth and remodeling; Transport and exchange of gasses and solutes; Rheology and biorheology; Endothelial cell biology and metabolism; Interactions between endothelium, smooth muscle, parenchymal cells, leukocytes and platelets; Regulation of vasomotor tone; and Microvascular structures, imaging and morphometry. Papers also describe innovations in experimental techniques and instrumentation for studying all aspects of microcirculatory structure and function.