Synthesis and characterization boron-doped hydroxyapatite for bone tissue engineering applications

IF 3.4 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Solid State Sciences Pub Date : 2025-05-24 DOI:10.1016/j.solidstatesciences.2025.107989

Sema Akbaba , Engin Pazarçeviren , Senem Özge Turaçlı Karagüven , Zafer Evis , Ayşen Tezcaner

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Abstract

In this study, the effect of dopant ratio on structural and biological properties of B-doped hydroxyapatite (HA) sintered at 500 °C was investigated for the first time. For this purpose, 1, 2, 4 and 8 mol% B-doped HA groups were synthesized. Presence of PO₄³⁻ and BO₃³⁻ groups were verified with Fourier-transform infrared spectroscopy (FTIR). X-ray diffraction (XRD) analysis revealed that increasing the B ratio led to a decreasing trend for HA phase percentage, crystallinity, and crystallite size. Similarly, Ca/(P + B) ratio decreased with increasing dopant ratio. B was incorporated into the HA structure with around 50 % yield. Moreover, mean particle size significantly decreased by B-doping for all groups. Concordantly, BET analysis revealed that the surface area of the groups increased with increasing B ratio. Overall, doping of HA with 4 mol% B was shown to provide both proliferative and osteogenic effects on human adipose derived stem cells (hADSCs). Our findings suggest that B-doped HA sintered at 500 °C holds promise for bone tissue engineering applications.

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骨组织工程用掺硼羟基磷灰石的合成与表征

本研究首次研究了掺杂比例对500℃烧结b掺杂羟基磷灰石（HA）结构和生物学性能的影响。为此，合成了1、2、4和8 mol% b掺杂的HA基团。用傅里叶变换红外光谱（FTIR）验证了PO43 -和BO33 -基团的存在。x射线衍射（XRD）分析表明，B比的增加导致HA相百分比、结晶度和晶粒尺寸呈下降趋势。Ca/(P + B)比值也随掺杂比的增加而减小。B被纳入HA结构，产率约为50%。此外，b掺杂显著降低了各组的平均粒径。BET分析结果显示，随着B比的增加，基团的表面积也随之增加。总的来说，用4 mol% B掺杂透明质酸被证明对人脂肪来源干细胞（hADSCs）具有增殖和成骨作用。我们的研究结果表明，在500°C下烧结的b掺杂HA有望用于骨组织工程应用。

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来源期刊

Solid State Sciences 化学-无机化学与核化学

CiteScore

6.60

自引率

2.90%

发文量

214

审稿时长

27 days

期刊介绍： Solid State Sciences is the journal for researchers from the broad solid state chemistry and physics community. It publishes key articles on all aspects of solid state synthesis, structure-property relationships, theory and functionalities, in relation with experiments. Key topics for stand-alone papers and special issues: -Novel ways of synthesis, inorganic functional materials, including porous and glassy materials, hybrid organic-inorganic compounds and nanomaterials -Physical properties, emphasizing but not limited to the electrical, magnetical and optical features -Materials related to information technology and energy and environmental sciences. The journal publishes feature articles from experts in the field upon invitation. Solid State Sciences - your gateway to energy-related materials.