Comparison of Breath Biomarker Studies for Early Diagnosis of Chronic Kidney Disease: A Review.

IF 3.7 4区医学 Q1 BIOCHEMICAL RESEARCH METHODS

Journal of breath research Pub Date : 2025-05-23 DOI:10.1088/1752-7163/addc8a

Yang Wang, Huachun Weng, Dongpo Xu, Suhua Zhang

引用次数: 0

Abstract

Chronic kidney disease (CKD) is a long-term progressive disease. The key to treatment lies in early diagnosis and timely intervention. How to achieve early diagnosis of CKD has always been an important challenge. Exhaled breath sample analysis, as an emerging method, has attracted much attention due to its non-invasiveness and the convenience of sample collection. Compared with the complex traditional detection methods, it is more suitable for large-scale screening. The main purpose of this review is to extensively collect relevant literature on the research of exhaled breath biomarkers for CKD, summarize the potential biomarkers discovered in these studies, and compare the similarities and differences. Through in-depth analysis of the causes of these differences and commonalities, this review aims to explore whether these potential exhaled breath biomarkers could serve as reliable indicators for the early diagnosis of CKD.

查看原文本刊更多论文

呼吸生物标志物在慢性肾脏疾病早期诊断中的比较研究综述

慢性肾脏疾病（CKD）是一种长期进行性疾病。治疗的关键在于早期诊断和及时干预。如何实现CKD的早期诊断一直是一个重要的挑战。呼气样本分析作为一种新兴的检测方法，因其无创性和采集方便而备受关注。与复杂的传统检测方法相比，更适合大规模筛选。本综述的主要目的是广泛收集CKD呼气生物标志物研究的相关文献，总结这些研究中发现的潜在生物标志物，并比较其异同。通过深入分析这些差异和共性的原因，本综述旨在探讨这些潜在的呼气生物标志物是否可以作为CKD早期诊断的可靠指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of breath research BIOCHEMICAL RESEARCH METHODS-RESPIRATORY SYSTEM

CiteScore

7.60

自引率

21.10%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Breath Research is dedicated to all aspects of scientific breath research. The traditional focus is on analysis of volatile compounds and aerosols in exhaled breath for the investigation of exogenous exposures, metabolism, toxicology, health status and the diagnosis of disease and breath odours. The journal also welcomes other breath-related topics. Typical areas of interest include: Big laboratory instrumentation: describing new state-of-the-art analytical instrumentation capable of performing high-resolution discovery and targeted breath research; exploiting complex technologies drawn from other areas of biochemistry and genetics for breath research. Engineering solutions: developing new breath sampling technologies for condensate and aerosols, for chemical and optical sensors, for extraction and sample preparation methods, for automation and standardization, and for multiplex analyses to preserve the breath matrix and facilitating analytical throughput. Measure exhaled constituents (e.g. CO2, acetone, isoprene) as markers of human presence or mitigate such contaminants in enclosed environments. Human and animal in vivo studies: decoding the ''breath exposome'', implementing exposure and intervention studies, performing cross-sectional and case-control research, assaying immune and inflammatory response, and testing mammalian host response to infections and exogenous exposures to develop information directly applicable to systems biology. Studying inhalation toxicology; inhaled breath as a source of internal dose; resultant blood, breath and urinary biomarkers linked to inhalation pathway. Cellular and molecular level in vitro studies. Clinical, pharmacological and forensic applications. Mathematical, statistical and graphical data interpretation.