Effects of individualized PEEP on pulmonary function, cerebral blood flow and postoperative cognitive function in patients undergoing laparoscopic radical resection of rectal cancer.

IF 3.4 2区 医学 Q2 ONCOLOGY
Xiaoyan Zhang, Jingjing Zhang, Caixia Zhao, Yichao Cai, Qing Yang, Caixia Yue, Kan Li
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引用次数: 0

Abstract

Objective: To evaluate the effects of individualized PEEP on pulmonary function, cerebral blood flow, and postoperative cognitive function in patients undergoing laparoscopic radical resection of rectal cancer.

Methods: 100 patients who underwent laparoscopic radical rectal cancer surgery at our hospital between August 2021 and May 2023 were randomized into two groups: the DP group (optimal PEEP group oriented to driving pressure) and the Cdyn group (optimal PEEP group oriented to pulmonary compliance). Anesthesia was induced in both groups with 0.3 mg/kg of remizolam + 0.15 mg/kg of CIS atracurium + 0.5 ug/kg of sufentanil. Lung ultrasound score (LUS), peak and plateau airway pressures (PEAK, PLAT), oxygenation index (OI), driving pressure (DP), and pulmonary dynamic compliance (Cdyn) were measured at different time points. Cerebral blood flow and cognitive function were also assessed. T0: before induction of anesthesia; T1: before postoperative extubation of the tracheal tube; T2: 1 h after extubation; T3: on the third postoperative day; T4: 5 min after determining the optimal PEEP; T5: 1 h after the establishment of pneumoperitoneum; T6: 2 h after the establishment of the pneumoperitoneum; T7: 20 min at the end of pneumoperitoneum.

Results: There were no significant differences in general information between the two groups, P > 0.05. Compared with the DP group, the Cdyn group had lower LUS at T3, higher PEAK at T5, T6, and T7, lower PLAT and OI at T6 and T7, lower DP at T4, T6, and T7, and lower Cdyn at T6 and T7, P < 0.05. The Cdyn group had lower cerebral blood flow at T4 and T6, P < 0.05. The Cdyn group had higher cognitive function at stage T3 as assessed by MMSE, P < 0.05.

Conclusion: PEEP guided by lung compliance improves pulmonary function, cerebral blood flow, and cognitive function, offering clinical benefits.

个体化PEEP对腹腔镜直肠癌根治术患者肺功能、脑血流及术后认知功能的影响
目的:探讨个体化PEEP对腹腔镜直肠癌根治术患者肺功能、脑血流量及术后认知功能的影响。方法:选取我院于2021年8月至2023年5月行腹腔镜直肠癌根治性手术的患者100例,随机分为两组:DP组(以驱动压力为导向的最佳PEEP组)和Cdyn组(以肺顺应性为导向的最佳PEEP组)。两组麻醉均采用0.3 mg/kg雷咪唑仑+ 0.15 mg/kg CIS阿曲库铵+ 0.5 ug/kg舒芬太尼。测定不同时间点的肺超声评分(LUS)、峰值、平台气道压力(peak、PLAT)、氧合指数(OI)、驱动压力(DP)、肺动态顺应性(Cdyn)。脑血流量和认知功能也被评估。T0:麻醉诱导前;T1:术后拔管前;T2:拔管后1 h;T3:术后第3天;T4:确定最佳PEEP后5min;T5:气腹建立后1 h;T6:气腹建立后2 h;T7:气腹结束时20min。结果:两组一般资料比较,差异无统计学意义(P < 0.05)。与DP组相比,Cdyn组T3时LUS较低,T5、T6、T7时PEAK较高,T6、T7时PLAT和OI较低,T4、T6、T7时DP较低,MMSE评估T6、T7、p4、T6、p3时Cdyn较低。结论:肺顺应性引导下的PEEP可改善肺功能、脑血流量和认知功能,具有临床益处。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BMC Cancer
BMC Cancer 医学-肿瘤学
CiteScore
6.00
自引率
2.60%
发文量
1204
审稿时长
6.8 months
期刊介绍: BMC Cancer is an open access, peer-reviewed journal that considers articles on all aspects of cancer research, including the pathophysiology, prevention, diagnosis and treatment of cancers. The journal welcomes submissions concerning molecular and cellular biology, genetics, epidemiology, and clinical trials.
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