{"title":"The effect of dietary micronutrient intake on abdominal aortic calcification: a study protocol for systematic review and meta-analysis.","authors":"Etsay Weldekidan Tsegay, Nigus Alemu Hailu, Meresa Berwo Mengesha, Zenawi Hagos Gufue","doi":"10.1136/bmjopen-2024-096551","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Healthy dietary choices have an important role in preventing chronic diseases such as cardiovascular disease (CVD). Increasing evidence suggests micronutrient intake (essential minerals and vitamins) is associated with abdominal aortic calcification (AAC), which is an advanced marker of CVD. However, the existing reports seem inconsistent. Some studies reported micronutrients are associated with a lower risk of AAC, while others have reported an increased risk. Therefore, this systematic review and meta-analysis sought to summarise the available evidence on the association of dietary micronutrient intake on AAC.</p><p><strong>Methods and analysis: </strong>A comprehensive systematic search of the PubMed/MEDLINE, EMBASE, Web of Science and Google Scholar databases from their inception up to September 1, 2024, will be conducted. All clinical studies that report eligible exposure/s (dietary micronutrient intake) and outcome/s (presence/severity of AAC) will be included, and this systematic review and meta-analysis protocol will be reported following the revised Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols guidelines. The risk of bias for observational studies will be assessed using the Newcastle-Ottawa Scale and publication bias will be evaluated through visual inspection of funnel plots and the Egger's and Begg's regression tests. The Der Simonian and Laird random-effects model meta-analysis will be calculated to provide pooled results, and the weighted risk ratio with their 95% confidence intervals will be presented.</p><p><strong>Ethics and dissemination: </strong>The results will be disseminated through publishing in a peer-reviewed journal and public presentations at relevant local, national and international conferences, workshops and symposiums. Ethical approval is not required as this is a systematic review of publicly available data.<b>PROSPERO registration number</b>CRD42024575902.</p>","PeriodicalId":9158,"journal":{"name":"BMJ Open","volume":"15 5","pages":"e096551"},"PeriodicalIF":2.4000,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104926/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMJ Open","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1136/bmjopen-2024-096551","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Healthy dietary choices have an important role in preventing chronic diseases such as cardiovascular disease (CVD). Increasing evidence suggests micronutrient intake (essential minerals and vitamins) is associated with abdominal aortic calcification (AAC), which is an advanced marker of CVD. However, the existing reports seem inconsistent. Some studies reported micronutrients are associated with a lower risk of AAC, while others have reported an increased risk. Therefore, this systematic review and meta-analysis sought to summarise the available evidence on the association of dietary micronutrient intake on AAC.
Methods and analysis: A comprehensive systematic search of the PubMed/MEDLINE, EMBASE, Web of Science and Google Scholar databases from their inception up to September 1, 2024, will be conducted. All clinical studies that report eligible exposure/s (dietary micronutrient intake) and outcome/s (presence/severity of AAC) will be included, and this systematic review and meta-analysis protocol will be reported following the revised Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols guidelines. The risk of bias for observational studies will be assessed using the Newcastle-Ottawa Scale and publication bias will be evaluated through visual inspection of funnel plots and the Egger's and Begg's regression tests. The Der Simonian and Laird random-effects model meta-analysis will be calculated to provide pooled results, and the weighted risk ratio with their 95% confidence intervals will be presented.
Ethics and dissemination: The results will be disseminated through publishing in a peer-reviewed journal and public presentations at relevant local, national and international conferences, workshops and symposiums. Ethical approval is not required as this is a systematic review of publicly available data.PROSPERO registration numberCRD42024575902.
健康的饮食选择对预防心血管疾病等慢性疾病有重要作用。越来越多的证据表明，微量营养素摄入（必需矿物质和维生素）与腹主动脉钙化（AAC）有关，这是心血管疾病的一个高级标志。然而，现有的报告似乎不一致。一些研究报告称，微量营养素与AAC的风险较低有关，而另一些研究报告称风险增加。因此，本系统综述和荟萃分析旨在总结膳食微量营养素摄入与AAC相关的现有证据。方法与分析：对PubMed/MEDLINE、EMBASE、Web of Science和谷歌Scholar数据库进行全面系统检索，检索时间截止到2024年9月1日。所有报告符合条件的暴露/s（膳食微量营养素摄入量）和结果/s （AAC的存在/严重程度）的临床研究将被纳入，该系统评价和荟萃分析方案将按照修订后的系统评价和荟萃分析方案指南的首选报告项目进行报告。观察性研究的偏倚风险将使用纽卡斯尔-渥太华量表进行评估，发表偏倚将通过漏斗图的目视检查和Egger’s和Begg’s回归检验进行评估。计算Der Simonian和Laird随机效应模型荟萃分析，提供汇总结果，并给出加权风险比及其95%置信区间。伦理和传播：研究结果将通过在同行评议的期刊上发表和在有关的地方、国家和国际会议、讲习班和专题讨论会上公开发表来传播。不需要伦理批准，因为这是对公开可用数据的系统审查。普洛斯彼罗注册号crd42024575902。
期刊介绍：
BMJ Open is an online, open access journal, dedicated to publishing medical research from all disciplines and therapeutic areas. The journal publishes all research study types, from study protocols to phase I trials to meta-analyses, including small or specialist studies. Publishing procedures are built around fully open peer review and continuous publication, publishing research online as soon as the article is ready.
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