Unlocking T-Cell Plasticity in the Tumor Microenvironment: Implications for Cancer Progression and Therapeutic Strategies

Xiao-Hong Ding, Xue-Pei Li, Fenfang Chen, Han Wang, Yi-Zhou Jiang
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Abstract

The tumor microenvironment (TME) is a complex and dynamic ecosystem crucial for cancer development and progression. Within this intricate milieu, T-cells constitute a heterogeneous population and serve as a cornerstone of antitumor immunity. Notably, T-cells can rapidly transition across a wide spectrum of phenotypic and functional states within the disrupted TME. Despite the crucial role of T-cells in cancer immunity, a comprehensive understanding of their plasticity within the TME remains limited. In this review, we delve into the functional plasticity and spatial distribution of T-cells in response to diverse microenvironmental conditions. Additionally, we review the plasticity of T-cell functional states during conventional therapies, highlighting their potential to enhance or limit therapeutic outcomes. Finally, we propose innovative therapeutic approaches that leverage T-cell plasticity to enhance clinical efficacy by regulating the immune response within the TME. By providing insights into the dynamics of T-cell behavior, this review highlights the promising potential of targeting T-cell plasticity as an immuno-sensitizer to refine therapeutic strategies and overcome current challenges in cancer treatment.

解锁肿瘤微环境中的t细胞可塑性:对癌症进展和治疗策略的影响
肿瘤微环境(tumor microenvironment, TME)是一个复杂而动态的生态系统,对癌症的发生和发展至关重要。在这种复杂的环境中,t细胞构成了一个异质群体,并作为抗肿瘤免疫的基石。值得注意的是,t细胞可以在被破坏的TME内快速过渡到广泛的表型和功能状态。尽管t细胞在癌症免疫中起着至关重要的作用,但对其在TME中的可塑性的全面了解仍然有限。在这篇综述中,我们深入研究了t细胞在不同微环境条件下的功能可塑性和空间分布。此外,我们回顾了常规治疗中t细胞功能状态的可塑性,强调了它们增强或限制治疗结果的潜力。最后,我们提出了创新的治疗方法,利用t细胞的可塑性,通过调节TME内的免疫反应来提高临床疗效。通过提供对t细胞行为动力学的见解,本综述强调了靶向t细胞可塑性作为免疫增敏剂的潜力,以完善治疗策略并克服当前癌症治疗中的挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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