Association between occupational and environmental dust exposure and autoimmune diseases: A systematic review and meta-analysis

IF 7.9 1区医学 Q1 IMMUNOLOGY

Journal of autoimmunity Pub Date : 2025-05-25 DOI:10.1016/j.jaut.2025.103440

Seunghyun Lee , Ah-Reum Jo , Youjin Kim , Wanhyung Lee , Xiaoxue Ma

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引用次数: 0

Abstract

Background

Occupational and environmental dust exposure is often overlooked, presenting significant public health concerns. Recent studies suggest it may increase the risk of autoimmune diseases. However, previous research has primarily focused on specific diseases or dust types, leaving the broader relationship unclear. A comprehensive meta-analysis are needed to clarify this connection.

Methods

We systematically searched PubMed and Google Scholar up to October 2023, following PRISMA guidelines. Study quality was assessed using standard tools, and a random-effects model was used to estimate pooled odds ratio (OR) and 95 % confidence interval (CI), with subgroup analyses by dust type and disease category.

Results

From 90 initial records, 19 studies were included. Dust exposure was significantly associated with increased autoimmune disease risk (OR 1.36, 95 % CI 1.13–1.59). Both occupational (OR 1.18, 95 % CI 1.11–1.26) and environmental dust exposure (OR 1.12, 95 % CI 1.04–1.20) were linked to higher risk. Subgroup analysis showed a strong association between silica exposure and connective tissue diseases, particularly granulomatosis with polyangiitis (OR 5.75, 95 % CI 2.79–8.71). Sensitivity analysis confirmed the findings, though publication bias was noted.

Conclusion

Our findings highlight a significant association between dust exposure and autoimmune disease risk, underscoring the need for stricter occupational safety measures and environmental regulations. Targeted interventions, such as improved ventilation systems and personal protective equipment (PPE), should be prioritized. Future research should focus on elucidating underlying mechanisms to inform prevention and treatment strategies.

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职业和环境粉尘暴露与自身免疫性疾病之间的关系：系统回顾和荟萃分析

职业和环境粉尘暴露往往被忽视，引起重大的公共卫生问题。最近的研究表明，它可能会增加自身免疫性疾病的风险。然而，之前的研究主要集中在特定的疾病或灰尘类型上，没有明确更广泛的关系。需要一个全面的荟萃分析来澄清这种联系。方法根据PRISMA指南，系统检索PubMed和谷歌Scholar，截止到2023年10月。使用标准工具评估研究质量，并使用随机效应模型估计合并优势比（OR）和95%置信区间（CI），并按粉尘类型和疾病类别进行亚组分析。结果从90份初始记录中纳入19项研究。粉尘暴露与自身免疫性疾病风险增加显著相关（OR 1.36, 95% CI 1.13-1.59）。职业（OR 1.18, 95% CI 1.11-1.26）和环境粉尘暴露（OR 1.12, 95% CI 1.04-1.20）都与较高的风险相关。亚组分析显示二氧化硅暴露与结缔组织疾病，特别是肉芽肿病合并多血管炎之间有很强的相关性（OR 5.75, 95% CI 2.79-8.71）。敏感性分析证实了这一发现，尽管存在发表偏倚。结论：我们的研究结果强调了粉尘暴露与自身免疫性疾病风险之间的显著关联，强调了更严格的职业安全措施和环境法规的必要性。应优先考虑有针对性的干预措施，如改进通风系统和个人防护装备。未来的研究应侧重于阐明潜在的机制，为预防和治疗策略提供信息。

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来源期刊

Journal of autoimmunity 医学-免疫学

CiteScore

27.90

自引率

1.60%

发文量

117

审稿时长

17 days

期刊介绍： The Journal of Autoimmunity serves as the primary publication for research on various facets of autoimmunity. These include topics such as the mechanism of self-recognition, regulation of autoimmune responses, experimental autoimmune diseases, diagnostic tests for autoantibodies, as well as the epidemiology, pathophysiology, and treatment of autoimmune diseases. While the journal covers a wide range of subjects, it emphasizes papers exploring the genetic, molecular biology, and cellular aspects of the field. The Journal of Translational Autoimmunity, on the other hand, is a subsidiary journal of the Journal of Autoimmunity. It focuses specifically on translating scientific discoveries in autoimmunity into clinical applications and practical solutions. By highlighting research that bridges the gap between basic science and clinical practice, the Journal of Translational Autoimmunity aims to advance the understanding and treatment of autoimmune diseases.