Theranostic: A Primer for Radiologists.

IF 2.9 3区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Seyed Ali Mirshahvalad, Mohsen Beheshti, Ur Metser, Di Maria Jiang, Rebecca Wong, Ibrahim Alrekhais, Patrick Veit-Haibach
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引用次数: 0

Abstract

Theranostic represents a transformative approach in precision medicine, integrating diagnostic imaging with targeted radiopharmaceutical therapy to enhance individualized disease management. Rooted in nuclear medicine, this approach uses molecular targeting agents labelled with diagnostic radioisotopes for imaging and therapeutic radioisotopes for treatment, ensuring a seamless transition from diagnosis to therapy. The field has evolved significantly in the last decade, with prostate-specific membrane antigen (PSMA)-targeted radioligand therapy transforming prostate cancer patient management and somatostatin receptor (SSTR)-targeted agents revolutionizing neuroendocrine tumour (NET) treatment. Considering its interdisciplinary nature, collaboration between nuclear medicine specialists, oncologists, radiologists, and other healthcare professionals is critical to refining clinical applications and improving patient outcomes. As prominent members of the theranostic team, radiologists play a pivotal role, from patient selection and imaging-based eligibility assessment to response evaluation and long-term monitoring. In this regard, advanced imaging modalities facilitate the precise evaluation of disease characteristics, guiding treatment decisions. Hence, as theranostics becomes increasingly integrated into patient management, radiologists face the need to be well-versed in both the technical aspects and clinical implications. In this review, we aimed to provide a primer for radiologists to gain a general insight into the theranostic field and its basic principles.

《治疗学:放射科医生入门》。
Theranostic代表了精准医学的一种变革方法,将诊断成像与靶向放射性药物治疗相结合,以增强个性化疾病管理。该方法植根于核医学,使用标记有诊断放射性同位素的分子靶向剂进行成像,使用标记有治疗性放射性同位素的分子靶向剂进行治疗,确保从诊断到治疗的无缝过渡。该领域在过去十年中发生了重大变化,前列腺特异性膜抗原(PSMA)靶向放射配体治疗改变了前列腺癌患者的管理,生长抑素受体(SSTR)靶向药物彻底改变了神经内分泌肿瘤(NET)的治疗。考虑到其跨学科性质,核医学专家、肿瘤学家、放射科医生和其他医疗保健专业人员之间的合作对于完善临床应用和改善患者预后至关重要。作为治疗团队的重要成员,放射科医生发挥着关键作用,从患者选择和基于成像的资格评估到反应评估和长期监测。在这方面,先进的成像方式有助于准确评估疾病特征,指导治疗决策。因此,随着治疗学越来越多地融入到患者管理中,放射科医生面临着精通技术方面和临床意义的需求。在这篇综述中,我们旨在为放射科医生提供一个入门,以获得对治疗领域及其基本原理的一般见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.20
自引率
12.90%
发文量
98
审稿时长
6-12 weeks
期刊介绍: The Canadian Association of Radiologists Journal is a peer-reviewed, Medline-indexed publication that presents a broad scientific review of radiology in Canada. The Journal covers such topics as abdominal imaging, cardiovascular radiology, computed tomography, continuing professional development, education and training, gastrointestinal radiology, health policy and practice, magnetic resonance imaging, musculoskeletal radiology, neuroradiology, nuclear medicine, pediatric radiology, radiology history, radiology practice guidelines and advisories, thoracic and cardiac imaging, trauma and emergency room imaging, ultrasonography, and vascular and interventional radiology. Article types considered for publication include original research articles, critically appraised topics, review articles, guest editorials, pictorial essays, technical notes, and letter to the Editor.
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