Breast Milk Application as a Natural Method for Umbilical Cord Care: A Community-Label 3-Arm Pilot Clinical Trial.

Maternal-fetal medicine (Wolters Kluwer Health, Inc.) Pub Date : 2024-10-11 eCollection Date: 2024-10-01 DOI:10.1097/FM9.0000000000000243

Bekalu Kassie Alemu, Leltework Yismaw Wondimagegn, Yibelu Bazezew, Tewachew Muche Liyeh, Abebaw Abeje Muluneh, Gedefaye Nibret Mihretie, Alekaw Sema, Melese Linger Endalifer, Getnet Gedefaw Azeze, Gashaw Garedew Woldeamanuel, Kenean Getaneh Tlaye, Wing Fong Lee, Yao Wang, Chi Chiu Wang

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Abstract

Objective: To compare the effects of human breast milk with those of chlorhexidine and the dry method on umbilical cord separation in Ethiopia.

Methods: This open-label 3-arm nonrandomized pilot clinical trial was conducted among 45 neonates (15 in each arm) with more than 630 home visits. After a standard cord cut, human breast milk, chlorhexidine, or nothing was applied once per day for 7 days. The primary outcome was the duration of cord separation, while the secondary outcomes were umbilical cord infection, neonatal fever, jaundice, feeding and breathing difficulty, and persistent crying.

Results: There were statistically significant differences in the time-to-cord separation between the human breast milk group and the chlorhexidine (P < 0.001) and dry alone (P = 0.038) groups. Compared to those of chlorhexidine, the rates of cord separation among human breast milk and the dry-alone group were 16.02, with 95% confidence intervals (3.81, 37.43; P < 0.001) and 3.15 (0.99, 10.00; P = 0.052), respectively. One (6.7%) cord site infection was observed in the dry-alone groups only.

Conclusion: This community-label study indicated that human breast milk application significantly shortened the length of umbilical cord separation time compared to chlorhexidine and dry methods. A large-scale randomized controlled trial is needed to confirm these results.

Registration: PACTR202310902873290; https://pactr.samrc.ac.za.

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应用母乳作为脐带护理的一种自然方法：一项社区标签3组临床试验。

目的：比较埃塞俄比亚人母乳、氯己定和干法在脐带分离中的效果。方法：对45例新生儿（每组15例）进行开放标签3组非随机临床试验，家访630多次。标准脐带剪断后，人母乳，氯己定，或不应用，每天一次，连续7天。主要结局为脐带分离时间，次要结局为脐带感染、新生儿发热、黄疸、喂养和呼吸困难、持续哭闹。结果：人乳组与洗必泰组（P < 0.001）和单干组（P = 0.038）在离脐带时间上差异有统计学意义。与氯己定组相比，人乳组和单独干乳组脐带分离率为16.02,95%可信区间为(3.81,37.43；P < 0.001)和3.15 (0.99,10.00；P = 0.052)。仅在单独干燥组中观察到1例（6.7%）脐带感染。结论：本社区标签研究表明，与氯己定和干法相比，人乳应用可显著缩短脐带分离时间。需要大规模随机对照试验来证实这些结果。注册:PACTR202310902873290;https://pactr.samrc.ac.za。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Maternal-fetal medicine (Wolters Kluwer Health, Inc.)

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