Relationship Between Facial Melasma and Ocular Photoaging Diseases.

Q1 Medicine
Lunla Udomwech, Chime Eden, Weeratian Tawanwongsri
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Abstract

Background/Objectives: Facial melasma is a common, chronic, and relapsing hyperpigmentation disorder, affecting up to 40% of adult women in Southeast Asia. Although most cases are mild, the condition may have a considerable psychological impact. Ocular photoaging diseases are also common and have been increasingly recognized in aging populations exposed to chronic sunlight. Ultraviolet (UV) radiation is implicated in both melasma and ocular photoaging; however, their relationship remains unclear. Methods: This cross-sectional study investigated the association between facial melasma and UV-induced ocular conditions among 315 participants aged 30-80 years at Walailak University Hospital, Thailand. Facial melasma was diagnosed clinically and dermoscopically, with severity assessed using the modified Melasma Area Severity Index. Ophthalmological examinations evaluated UV-related ocular conditions, including pinguecula, pterygium, climatic droplet keratopathy, cataracts, and age-related macular degeneration. Logistic regression analyses were performed, adjusting for age, sex, and sun exposure. Results: Facial melasma was identified in 66.0% of participants (n = 208), and nuclear cataracts were significantly associated with melasma (adjusted odds ratio, 2.590; 95% confidence interval, 1.410-4.770; p = 0.002). Additionally, melasma severity correlated with nuclear cataract severity (ρ = 0.186, p = 0.001). Other ocular conditions were not significantly associated with melasma. Conclusions: These findings suggest a shared UV-related pathogenesis between facial melasma and nuclear cataracts. Sun protection measures, including regular sunscreen use, UV-blocking eyewear, and wide-brimmed hats, may help mitigate the risk of both conditions. Further multicenter studies are warranted to confirm these findings and explore the underlying mechanisms.

面部黄褐斑与眼部光老化疾病的关系。
背景/目的:面部黄褐斑是一种常见的、慢性的、反复发作的色素沉着症,影响东南亚高达40%的成年女性。虽然大多数情况是轻微的,但这种情况可能会产生相当大的心理影响。眼部光老化疾病也很常见,并且在长期暴露于阳光下的老年人群中得到越来越多的认识。紫外线(UV)辐射与黄褐斑和眼部光老化有关;然而,他们的关系仍不清楚。方法:本横断面研究调查了泰国Walailak大学医院315名年龄在30-80岁的参与者面部黄褐斑与紫外线引起的眼部状况之间的关系。面部黄褐斑经临床和皮肤镜诊断,并用改良的黄褐斑面积严重程度指数评估严重程度。眼科检查评估了与紫外线相关的眼部疾病,包括鼻窦炎、翼状胬肉、气候性角膜液滴病、白内障和年龄相关性黄斑变性。进行了逻辑回归分析,调整了年龄、性别和日晒。结果:66.0%的参与者(n = 208)发现面部黄褐斑,核性白内障与黄褐斑显著相关(校正优势比为2.590;95%置信区间为1.410-4.770;P = 0.002)。此外,黄褐斑严重程度与核性白内障严重程度相关(ρ = 0.186, p = 0.001)。其他眼部疾病与黄褐斑无显著相关性。结论:这些发现提示面部黄褐斑和核性白内障具有共同的紫外线相关发病机制。防晒措施,包括定期使用防晒霜,戴防紫外线眼镜和宽边帽,可能有助于减轻这两种情况的风险。需要进一步的多中心研究来证实这些发现并探索潜在的机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
9.00
自引率
0.00%
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审稿时长
6 weeks
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