Advancing oral cancer care: nanomaterial-driven diagnostic and therapeutic innovations.

IF 5.3 2区医学 Q2 CELL BIOLOGY

Cell Biology and Toxicology Pub Date : 2025-05-23 DOI:10.1007/s10565-025-10027-5

Yuwen Chen, Sijia Cai, Fa-Yu Liu, Ming Liu

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Abstract

The advent of nanotechnology has significantly advanced the diagnosis and treatment of oral cancer, offering more precise and efficient therapeutic strategies. This review presents a comprehensive overview of recent developments in the application of nanotechnology to oral cancer management. It begins with an overview of the epidemiology of oral cancer and outlines current diagnostic and therapeutic methods. The classification and advantages of various nanomaterials are then introduced. The paper thoroughly explores the use of nanomaterials as drug delivery systems (DDSs), imaging contrast agents, and therapeutic tools, with particular emphasis on multifunctional nanoplatforms that integrate diagnostics and therapy. These platforms enable real-time monitoring and immediate therapeutic response, offering innovative approaches for early detection and intervention. Despite these promising advances, several challenges persist, including issues related to biocompatibility, clearance, targeting specificity, and clinical translation. The review concludes by highlighting current limitations and proposing future directions for the clinical application of nanotechnology in oral cancer treatment.

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推进口腔癌护理：纳米材料驱动的诊断和治疗创新。

纳米技术的出现极大地促进了口腔癌的诊断和治疗，提供了更精确和有效的治疗策略。本文综述了纳米技术在口腔癌治疗中的应用的最新进展。它首先概述口腔癌的流行病学，并概述当前的诊断和治疗方法。介绍了各种纳米材料的分类和优点。本文深入探讨了纳米材料作为药物传递系统（dds）、成像造影剂和治疗工具的使用，特别强调了集成诊断和治疗的多功能纳米平台。这些平台能够实现实时监测和即时治疗反应，为早期发现和干预提供了创新方法。尽管有这些有希望的进展，一些挑战仍然存在，包括与生物相容性、清除率、靶向特异性和临床翻译相关的问题。本文总结了目前纳米技术在口腔癌治疗中的临床应用的局限性，并提出了未来的发展方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Biology and Toxicology 生物-毒理学

CiteScore

9.90

自引率

4.90%

发文量

101

审稿时长

>12 weeks

期刊介绍： Cell Biology and Toxicology (CBT) is an international journal focused on clinical and translational research with an emphasis on molecular and cell biology, genetic and epigenetic heterogeneity, drug discovery and development, and molecular pharmacology and toxicology. CBT has a disease-specific scope prioritizing publications on gene and protein-based regulation, intracellular signaling pathway dysfunction, cell type-specific function, and systems in biomedicine in drug discovery and development. CBT publishes original articles with outstanding, innovative and significant findings, important reviews on recent research advances and issues of high current interest, opinion articles of leading edge science, and rapid communication or reports, on molecular mechanisms and therapies in diseases.