Nanosensing doxorubicin: a new frontier in medicinal chemistry

IF 2.6 4区医学 Q3 CHEMISTRY, MEDICINAL

Medicinal Chemistry Research Pub Date : 2025-05-08 DOI:10.1007/s00044-025-03421-5

Nazila Karzad, Samad Rastmanesh, Elham Shaterian, Hamed Shaterian, Ahmad Mobed

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Abstract

The advent of nanosensing technologies marks a significant advancement in medicinal chemistry, particularly in the detection and monitoring of therapeutic agents such as doxorubicin. This review aims to elucidate the development of cutting-edge biosensor technologies specifically tailored for the sensitive and selective detection of doxorubicin, a cornerstone chemotherapeutic agent. We critically analyze various recently developed nanosensors, including electrochemical sensors and optical sensors, highlighting their distinct mechanisms, advantages, and limitations. Unlike previous literature, this review synthesizes current research findings to provide a comprehensive overview of how these innovative nanosensing platforms can enhance drug monitoring, improve therapeutic outcomes, and support personalized medicine approaches. By addressing the existing challenges in doxorubicin detection, our findings underscore the transformative potential of integrating nanotechnology with biosensing applications, ultimately contributing to more effective cancer treatment strategies.

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纳米感应阿霉素：药物化学的新前沿

纳米传感技术的出现标志着药物化学的重大进步，特别是在检测和监测治疗剂如阿霉素方面。本综述旨在阐明尖端生物传感器技术的发展，专门用于敏感和选择性检测阿霉素，一种基石化疗药物。我们批判性地分析了最近发展的各种纳米传感器，包括电化学传感器和光学传感器，突出了它们独特的机制，优势和局限性。与以前的文献不同，本文综合了当前的研究成果，全面概述了这些创新的纳米传感平台如何加强药物监测，改善治疗结果，并支持个性化医疗方法。通过解决阿霉素检测中存在的挑战，我们的研究结果强调了将纳米技术与生物传感应用相结合的变革潜力，最终有助于更有效的癌症治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medicinal Chemistry Research 医学-医药化学

CiteScore

4.70

自引率

3.80%

发文量

162

审稿时长

5.0 months

期刊介绍： Medicinal Chemistry Research (MCRE) publishes papers on a wide range of topics, favoring research with significant, new, and up-to-date information. Although the journal has a demanding peer review process, MCRE still boasts rapid publication, due in part, to the length of the submissions. The journal publishes significant research on various topics, many of which emphasize the structure-activity relationships of molecular biology.