DNA methylation modification: Dawn of research on cornea-related diseases

IF 5.2 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Life sciences Pub Date : 2025-05-22 DOI:10.1016/j.lfs.2025.123757

Quanhao Pan , Xiaoning Ge , Di Wang , Yuxi He

引用次数: 0

Abstract

DNA methylation is a significant form of epigenetic modification that plays a crucial role in the occurrence and progression of diseases by regulating gene expression. Recent advancements in our understanding of DNA methylation have demonstrated its involvement in corneal damage repair and various corneal diseases. This article reviews the mechanisms and effects of DNA methylation modifications in corneal injury repair, keratoconus, corneal dystrophy, keratitis, and other related conditions. The aim is to enhance our understanding of the vital role of DNA methylation in the pathogenesis of corneal injuries and the development of cornea-related diseases. The phenomenon of DNA methylation in these conditions may offer new ideas and insights for therapeutic approaches.

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DNA甲基化修饰：角膜相关疾病研究的曙光

DNA甲基化是一种重要的表观遗传修饰形式，通过调节基因表达在疾病的发生和发展中起着至关重要的作用。近年来，我们对DNA甲基化的理解取得了进展，这表明它参与了角膜损伤修复和各种角膜疾病。本文综述了DNA甲基化修饰在角膜损伤修复、圆锥角膜、角膜营养不良、角膜炎等相关疾病中的机制和作用。目的是增强我们对DNA甲基化在角膜损伤发病机制和角膜相关疾病发展中的重要作用的理解。这些情况下的DNA甲基化现象可能为治疗方法提供新的思路和见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Life sciences 医学-药学

CiteScore

12.20

自引率

1.60%

发文量

841

审稿时长

6 months

期刊介绍： Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. The journal emphasizes the understanding of mechanism that is relevant to all aspects of human disease and translation to patients. All articles are rigorously reviewed. The Journal favors publication of full-length papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms. Articles that merely report observations are rarely accepted. Recommendations from the Declaration of Helsinki or NIH guidelines for care and use of laboratory animals must be adhered to. Articles should be written at a level accessible to readers who are non-specialists in the topic of the article themselves, but who are interested in the research. The Journal welcomes reviews on topics of wide interest to investigators in the life sciences. We particularly encourage submission of brief, focused reviews containing high-quality artwork and require the use of mechanistic summary diagrams.