Photoinduced β-fragmentation for efficient pyridine alkylation via N-alkoxypyridinium salts

IF 4.6 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2025-05-23 DOI:10.1039/d5qo00400d

Heng Liu, Fangrui Wu, Zhidong Wan, Changhai Yue, Changsheng Wang, Chengkou Liu, Yuguang Li, Zheng Fang, Hong Qin, Zhao Yang

引用次数: 0

Abstract

Pyridine is a key structural motif in pharmaceuticals, and its functionalization is of great research value. We present an efficient alkylation method using N-alkoxypyridinium salts as bifunctional reagents. This protocol operates under mild conditions and offers a broad substrate scope, enabling rapid molecular construction via β-fragmentation with low catalyst loading.

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利用n -烷氧基吡啶盐进行有效吡啶烷基化的光诱导β碎裂

吡啶是药物中重要的结构基序，其功能化具有重要的研究价值。提出了一种以n -烷氧基吡啶盐为双功能试剂的高效烷基化方法。该方案在温和的条件下运行，提供了广泛的底物范围，通过低催化剂负载的β裂解实现快速分子构建。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.