Jonathan M Williams, Melissa A Hilmes, Lisa R Letourneau-Freiberg, Balamurugan Kandasamy, Demetra Braun, Siri Atma W Greeley, Louis Philipson, Alvin C Powers, John Virostko, Daniel J Moore, Jordan J Wright
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Abstract
Article highlights: Individuals with type 1 diabetes (T1D) have a markedly smaller pancreas, but the mechanism responsible for the reduction in size is unknown. How pancreas volume differs in individuals with specific forms of monogenic diabetes and how pancreas volume relates to the severity of insulin deficiency are unknown. Measured by MRI, individuals with permanent neonatal diabetes due to an INS gene mutation (INS-PND) or the HNF1B gene associated with maturity onset diabetes of the young had smaller pancreas than individuals without diabetes. Across all types of monogenic diabetes, individuals receiving insulin replacement therapy had smaller pancreas than individuals not using insulin. These results support the conclusion that insulin deficiency is a major factor contributing to changes in pancreas volume in T1D, INS-PND, and other forms of monogenic diabetes.
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