{"title":"The Role of Surgery for Local Consolidative Therapy in the Management of Oligometastatic Disease.","authors":"Rajika Jindani, Kyle G Mitchell, Mara B Antonoff","doi":"10.1053/j.semtcvs.2025.05.003","DOIUrl":null,"url":null,"abstract":"<p><p>Oligometastatic non-small cell lung cancer (NSCLC) constitutes a distinct form of disease with limited metastatic burden, which may benefit in terms of disease control and overall survival from local consolidative therapy (LCT). Pulmonary resection has emerged as a valuable component of LCT, demonstrating improvements in progression-free and overall survival for appropriately selected patients. This review examines the evolving role of surgery in the management of oligometastatic NSCLC, emphasizing survival benefits, biological rationale, surgical complexities, disparities in care, and ongoing trials. Emerging research integrating biomarkers, novel pharmacotherapy, and advanced surgical techniques offers new opportunities to refine patient selection and improve outcomes. Addressing barriers and advancing multidisciplinary approaches will be critical to fully realize the benefits of surgery in this context.</p>","PeriodicalId":48592,"journal":{"name":"Seminars in Thoracic and Cardiovascular Surgery","volume":" ","pages":""},"PeriodicalIF":2.5000,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in Thoracic and Cardiovascular Surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1053/j.semtcvs.2025.05.003","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
Abstract
Oligometastatic non-small cell lung cancer (NSCLC) constitutes a distinct form of disease with limited metastatic burden, which may benefit in terms of disease control and overall survival from local consolidative therapy (LCT). Pulmonary resection has emerged as a valuable component of LCT, demonstrating improvements in progression-free and overall survival for appropriately selected patients. This review examines the evolving role of surgery in the management of oligometastatic NSCLC, emphasizing survival benefits, biological rationale, surgical complexities, disparities in care, and ongoing trials. Emerging research integrating biomarkers, novel pharmacotherapy, and advanced surgical techniques offers new opportunities to refine patient selection and improve outcomes. Addressing barriers and advancing multidisciplinary approaches will be critical to fully realize the benefits of surgery in this context.
期刊介绍：
Seminars in Thoracic and Cardiovascular Surgery is devoted to providing a forum for cardiothoracic surgeons to disseminate and discuss important new information and to gain insight into unresolved areas of question in the specialty. Each issue presents readers with a selection of original peer-reviewed articles accompanied by editorial commentary from specialists in the field. In addition, readers are offered valuable invited articles: State of Views editorials and Current Readings highlighting the latest contributions on central or controversial issues. Another prized feature is expert roundtable discussions in which experts debate critical questions for cardiothoracic treatment and care. Seminars is an invitation-only publication that receives original submissions transferred ONLY from its sister publication, The Journal of Thoracic and Cardiovascular Surgery. As we continue to expand the reach of the Journal, we will explore the possibility of accepting unsolicited manuscripts in the future.
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