The Role of Fatty Acid Binding Protein 7 in Neurological Diseases.

IF 4.3 2区医学 Q1 NEUROSCIENCES

Molecular Neurobiology Pub Date : 2025-11-01 Epub Date: 2025-05-22 DOI:10.1007/s12035-025-05071-5

Yingxi Chen, Jiarui Liu, Yurou He, Yang Lü, Weihua Yu

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Abstract

Fatty acid binding protein 7 (FABP7) is a pivotal cytoplasmic protein involved in the transport and metabolism of fatty acids, with critical functions in the nervous system. This review highlights recent advances in understanding the role and mechanisms of FABP7 in neurological diseases. It begins with an overview of FABP7's distribution and expression in the nervous system, emphasizing its involvement in essential biological processes such as lipid metabolism, energy regulation, synaptic transmission, cell growth, and neuroinflammation. This review also explores FABP7's associations with major neurological disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), schizophrenia, and depression, shedding light on its dual roles in neuroprotection and neurodegeneration. These findings position FABP7 as a promising target for novel therapeutic strategies. By unraveling its precise mechanisms and contributions to both neural health and disease, future research on FABP7 has the potential to revolutionize treatments for neurological disorders, offering innovative directions for therapeutic development.

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脂肪酸结合蛋白7在神经系统疾病中的作用。

脂肪酸结合蛋白7 （Fatty acid binding protein 7, FABP7）是参与脂肪酸转运和代谢的关键细胞质蛋白，在神经系统中具有重要功能。本文综述了FABP7在神经系统疾病中的作用和机制的最新进展。首先概述了FABP7在神经系统中的分布和表达，强调了其在脂质代谢、能量调节、突触传递、细胞生长和神经炎症等基本生物过程中的作用。本综述还探讨了FABP7与主要神经系统疾病（包括阿尔茨海默病（AD）、帕金森病（PD）、精神分裂症和抑郁症）的关联，揭示了其在神经保护和神经退行性变中的双重作用。这些发现将FABP7定位为新的治疗策略的有希望的靶点。通过揭示其对神经健康和疾病的精确机制和贡献，未来对FABP7的研究有可能彻底改变神经疾病的治疗，为治疗发展提供创新方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Neurobiology 医学-神经科学

CiteScore

9.00

自引率

2.00%

发文量

480

审稿时长

1 months

期刊介绍： Molecular Neurobiology is an exciting journal for neuroscientists needing to stay in close touch with progress at the forefront of molecular brain research today. It is an especially important periodical for graduate students and "postdocs," specifically designed to synthesize and critically assess research trends for all neuroscientists hoping to stay active at the cutting edge of this dramatically developing area. This journal has proven to be crucial in departmental libraries, serving as essential reading for every committed neuroscientist who is striving to keep abreast of all rapid developments in a forefront field. Most recent significant advances in experimental and clinical neuroscience have been occurring at the molecular level. Until now, there has been no journal devoted to looking closely at this fragmented literature in a critical, coherent fashion. Each submission is thoroughly analyzed by scientists and clinicians internationally renowned for their special competence in the areas treated.