Intervention Role of APOE in CNS Diseases: APOE Actions and APOE Neurogenesis Capability.

IF 4.3 2区医学 Q1 NEUROSCIENCES

Molecular Neurobiology Pub Date : 2025-11-01 Epub Date: 2025-05-22 DOI:10.1007/s12035-025-05028-8

Wenhua Li, Suya Ma, Min Li

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引用次数: 0

Abstract

Neurogenesis is a biological process in which new neurons are generated from neural stem cells (NSCs) in specific neural niches in the brain. Impaired neurogenesis, characterized by the progressive loss of neurons, leads to cognitive and motor disabilities and is a hallmark of central nervous system (CNS) diseases. Conversely, enhancing neurogenesis has been shown to alleviate the symptoms of CNS diseases. Apolipoprotein E (APOE) is a protein that plays various biological roles in CNS diseases. Emerging research indicates that APOE is involved in adult neurogenesis, which is crucial for maintaining the neural progenitor pool in the dentate gyrus (DG) and synaptic activity. Therefore, APOE could be a therapeutic target for promoting neurogenesis in the treatment and intervention of CNS diseases. In this context, we present a comprehensive overview of the clinical evidence supporting the role of APOE in CNS diseases on the basis of a meta-analysis. We also discuss the neurogenic potential of APOE, which has significant implications not only for understanding the biological underpinnings of neurological diseases but also for developing novel treatment strategies for CNS diseases.

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APOE在中枢神经系统疾病中的干预作用：APOE的作用和APOE神经发生能力。

神经发生是神经干细胞（NSCs）在大脑特定神经龛中产生新神经元的生物学过程。神经发生受损，以神经元的进行性丧失为特征，导致认知和运动障碍，是中枢神经系统（CNS）疾病的标志。相反，增强神经发生已被证明可以减轻中枢神经系统疾病的症状。载脂蛋白E （APOE）是一种在中枢神经系统疾病中发挥多种生物学作用的蛋白。新的研究表明，APOE参与成人神经发生，这对于维持齿状回（DG）的神经祖细胞池和突触活性至关重要。因此，APOE在中枢神经系统疾病的治疗和干预中可能成为促进神经发生的治疗靶点。在此背景下，我们在荟萃分析的基础上全面概述了支持APOE在中枢神经系统疾病中的作用的临床证据。我们还讨论了APOE的神经源性潜力，这不仅对理解神经系统疾病的生物学基础，而且对开发针对中枢神经系统疾病的新治疗策略具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Neurobiology 医学-神经科学

CiteScore

9.00

自引率

2.00%

发文量

480

审稿时长

1 months

期刊介绍： Molecular Neurobiology is an exciting journal for neuroscientists needing to stay in close touch with progress at the forefront of molecular brain research today. It is an especially important periodical for graduate students and "postdocs," specifically designed to synthesize and critically assess research trends for all neuroscientists hoping to stay active at the cutting edge of this dramatically developing area. This journal has proven to be crucial in departmental libraries, serving as essential reading for every committed neuroscientist who is striving to keep abreast of all rapid developments in a forefront field. Most recent significant advances in experimental and clinical neuroscience have been occurring at the molecular level. Until now, there has been no journal devoted to looking closely at this fragmented literature in a critical, coherent fashion. Each submission is thoroughly analyzed by scientists and clinicians internationally renowned for their special competence in the areas treated.