Xinqing Lin, Hui Guo, Wei Zhao, Min Li, Gen Lin, Qian Chu, Enguo Chen, Liang'an Chen, Rui Chen, Tianqing Chu, Haiyi Deng, Yu Deng, Hangming Dong, Wen Dong, Yuchao Dong, Wenfeng Fang, Xin Gan, Liang Gong, Yingying Gu, Qian Han, Yue Hao, Yong He, Chengping Hu, Jie Hu, Yi Hu, Yongliang Jiang, Yang Jin, Fen Lan, Weimin Li, Weifeng Li, Wenhua Liang, Anwen Liu, Dan Liu, Ming Liu, Mengjie Liu, Zhuo Liu, Zhefeng Liu, Qun Luo, Liyun Miao, Chuanyong Mu, Pinhua Pan, Ping Peng, Jianwen Qin, Yinyin Qin, Panxiao Shen, Minhua Shi, Yong Song, Chunxia Su, Jin Su, Xin Su, Xiaowu Tan, Kejing Tang, Xiaomei Tang, Panwen Tian, Binchao Wang, Huijuan Wang, Kai Wang, Mengzhao Wang, Qi Wang, Wenxian Wang, Zhijie Wang, Di Wu, Fei Xu, Yan Xu, Chunwei Xu, Zhanhong Xie, Xiaohong Xie, Boyan Yang, Meng Yang, Feng Ye, Xiaoqun Ye, Zongyang Yu, Jian Zhang, Jianqing Zhang, Xiaoju Zhang, Fei Zhao, Xiaobin Zheng, Bo Zhu, Zhengfei Zhu, Jianya Zhou, Jianying Zhou, Min Zhou, Qing Zhou, Zihua Zou, Biniam Kidane, Elena Bignami, Fumio Sakamaki, Giandomenico Roviello, Hirokazu Taniguchi, Kyeongman Jeon, Lenko Saric, Miguel Ariza-Prota, Ninh M La-Beck, Nobuhiro Kanaji, Satoshi Watanabe, Takehito Shukuya, Tomohiro Akaba, Tracy L Leong, Wolfgang Gesierich, Yasuhiko Koga, Yoshinori Tanino, Yuji Uehara, Shiyue Li, Rongchang Chen, Chengzhi Zhou
{"title":"Expert consensus on cancer treatment-related lung injury.","authors":"Xinqing Lin, Hui Guo, Wei Zhao, Min Li, Gen Lin, Qian Chu, Enguo Chen, Liang'an Chen, Rui Chen, Tianqing Chu, Haiyi Deng, Yu Deng, Hangming Dong, Wen Dong, Yuchao Dong, Wenfeng Fang, Xin Gan, Liang Gong, Yingying Gu, Qian Han, Yue Hao, Yong He, Chengping Hu, Jie Hu, Yi Hu, Yongliang Jiang, Yang Jin, Fen Lan, Weimin Li, Weifeng Li, Wenhua Liang, Anwen Liu, Dan Liu, Ming Liu, Mengjie Liu, Zhuo Liu, Zhefeng Liu, Qun Luo, Liyun Miao, Chuanyong Mu, Pinhua Pan, Ping Peng, Jianwen Qin, Yinyin Qin, Panxiao Shen, Minhua Shi, Yong Song, Chunxia Su, Jin Su, Xin Su, Xiaowu Tan, Kejing Tang, Xiaomei Tang, Panwen Tian, Binchao Wang, Huijuan Wang, Kai Wang, Mengzhao Wang, Qi Wang, Wenxian Wang, Zhijie Wang, Di Wu, Fei Xu, Yan Xu, Chunwei Xu, Zhanhong Xie, Xiaohong Xie, Boyan Yang, Meng Yang, Feng Ye, Xiaoqun Ye, Zongyang Yu, Jian Zhang, Jianqing Zhang, Xiaoju Zhang, Fei Zhao, Xiaobin Zheng, Bo Zhu, Zhengfei Zhu, Jianya Zhou, Jianying Zhou, Min Zhou, Qing Zhou, Zihua Zou, Biniam Kidane, Elena Bignami, Fumio Sakamaki, Giandomenico Roviello, Hirokazu Taniguchi, Kyeongman Jeon, Lenko Saric, Miguel Ariza-Prota, Ninh M La-Beck, Nobuhiro Kanaji, Satoshi Watanabe, Takehito Shukuya, Tomohiro Akaba, Tracy L Leong, Wolfgang Gesierich, Yasuhiko Koga, Yoshinori Tanino, Yuji Uehara, Shiyue Li, Rongchang Chen, Chengzhi Zhou","doi":"10.21037/jtd-2025-292","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Although advancements in cancer therapies have substantially improved the survival of cancer patients, these treatments may also result in acute or chronic lung injury. Cancer treatment-related lung injury (CTLI) presents with a diverse array of clinical manifestations and can involve multiple sites. Due to the lack of specific diagnostic protocols, CTLI can deteriorate rapidly and may be life-threatening if not promptly addressed. Unfortunately, there is no universally accepted consensus document on the diagnosis and management of CTLI.</p><p><strong>Methods: </strong>A multidisciplinary panel comprising experts from respiratory and critical care medicine, oncology, radiation oncology, thoracic surgery, radiology, pathology, infectious diseases, pharmacy, and rehabilitation medicine participated in this consensus development. Through a systematic literature review and detailed panel discussions, the team formulated nine key recommendations.</p><p><strong>Results: </strong>This consensus document addresses the concept, epidemiology, pathogenesis, risk factors, diagnostic approach, evaluation workflow, management strategies, differential diagnosis, type-specific management and clinical staging of CTLI. Emphasis is placed on raising awareness among clinicians and therapeutic practices through comprehensive guidelines.</p><p><strong>Conclusions: </strong>The consensus provides a detailed diagnostic protocol for CTLI and introduces a structured management framework based on grading, typing, and staging. It highlights the critical role of multidisciplinary team (MDT) collaboration and emphasizes the need for individualized, whole-process patient care strategies to optimize clinical outcomes.</p>","PeriodicalId":17542,"journal":{"name":"Journal of thoracic disease","volume":"17 4","pages":"1844-1875"},"PeriodicalIF":2.1000,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090108/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of thoracic disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.21037/jtd-2025-292","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/28 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Although advancements in cancer therapies have substantially improved the survival of cancer patients, these treatments may also result in acute or chronic lung injury. Cancer treatment-related lung injury (CTLI) presents with a diverse array of clinical manifestations and can involve multiple sites. Due to the lack of specific diagnostic protocols, CTLI can deteriorate rapidly and may be life-threatening if not promptly addressed. Unfortunately, there is no universally accepted consensus document on the diagnosis and management of CTLI.
Methods: A multidisciplinary panel comprising experts from respiratory and critical care medicine, oncology, radiation oncology, thoracic surgery, radiology, pathology, infectious diseases, pharmacy, and rehabilitation medicine participated in this consensus development. Through a systematic literature review and detailed panel discussions, the team formulated nine key recommendations.
Results: This consensus document addresses the concept, epidemiology, pathogenesis, risk factors, diagnostic approach, evaluation workflow, management strategies, differential diagnosis, type-specific management and clinical staging of CTLI. Emphasis is placed on raising awareness among clinicians and therapeutic practices through comprehensive guidelines.
Conclusions: The consensus provides a detailed diagnostic protocol for CTLI and introduces a structured management framework based on grading, typing, and staging. It highlights the critical role of multidisciplinary team (MDT) collaboration and emphasizes the need for individualized, whole-process patient care strategies to optimize clinical outcomes.
期刊介绍：
The Journal of Thoracic Disease (JTD, J Thorac Dis, pISSN: 2072-1439; eISSN: 2077-6624) was founded in Dec 2009, and indexed in PubMed in Dec 2011 and Science Citation Index SCI in Feb 2013. It is published quarterly (Dec 2009- Dec 2011), bimonthly (Jan 2012 - Dec 2013), monthly (Jan. 2014-) and openly distributed worldwide. JTD received its impact factor of 2.365 for the year 2016. JTD publishes manuscripts that describe new findings and provide current, practical information on the diagnosis and treatment of conditions related to thoracic disease. All the submission and reviewing are conducted electronically so that rapid review is assured.
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