Increased insulin-like growth factor-1 concentrations in paediatric suprasellar low-grade glioma: an international multicentre study.

IF 5.3 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Ichelle M A A van Roessel, Boudewijn Bakker, Antoinette Y N Schouten-van Meeteren, Wim J E Tissing, Hoong-Wei Gan, Hanneke M van Santen
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引用次数: 0

Abstract

Objective: The objective of this study was to assess the prevalence of elevated insulin-like growth factor (IGF)-1 in children with suprasellar low-grade glioma (LGG) and explore the course of IGF-1 over time and its association with anthropometrics, hypothalamic syndrome, tumour characteristics, and tumour behaviour.

Design: This retrospective study included children from the Netherlands and the United Kingdom diagnosed with a suprasellar LGG under the age of 18 between 2003 and 2023, with a minimum 1-year follow-up. Elevated IGF-1 was defined as IGF-1 standard deviation score (SDS) >+2.0 for age and biological sex, without growth hormone use.

Results: We included 235 patients with a median age at brain tumour diagnosis of 3.8 years (IQR 1.7-7.1). Elevated IGF-1 was observed in 73 patients (31.1%) at any time point. At tumour diagnosis, 15.2% of the 138 children tested showed elevated IGF-1. Elevated IGF-1 was associated with younger age at tumour diagnosis (P = .004), neurofibromatosis type 1 (NF1; P = .028), and diencephalic syndrome (P = .047). In 55 of the 73 patients with elevated IGF-1 (75.3%), IGF-1 normalized spontaneously over time. Final height SDS corrected for target height SDS was not associated with having had an elevated IGF-1 (P = .113). No difference was found in the number of tumour progressions.

Conclusions: Increased IGF-1 concentrations are commonly observed in children with suprasellar LGG, especially in younger children, those with an NF1 mutation, or during underweight. Elevation of IGF-1 can resolve over time, and the absence of an effect on final height or on tumour progressions seems reassuring.

儿童鞍上低级别胶质瘤中胰岛素样生长因子-1浓度升高:一项国际多中心研究
目的:本研究的目的是评估儿童鞍上低级别胶质瘤(LGG)中胰岛素样生长因子(IGF)-1升高的患病率,并探讨IGF-1随时间的变化过程及其与人体测量学、下丘脑综合征、肿瘤特征和肿瘤行为的关系。设计:本回顾性研究纳入2003年至2023年间荷兰和英国18岁以下诊断为鞍上LGG的儿童,随访时间至少1年。在未使用生长激素的情况下,年龄和生理性别的IGF-1标准偏差评分(SDS)为>+2.0。结果:我们纳入了235例脑肿瘤诊断时的中位年龄为3.8岁(IQR为1.7-7.1)的患者。在任何时间点,73例患者(31.1%)观察到IGF-1升高。在肿瘤诊断时,138名接受检测的儿童中有15.2%显示IGF-1升高。IGF-1升高与肿瘤诊断年龄较低(P = 0.004)、1型神经纤维瘤病(NF1;P = 0.028)和间脑综合征(P = 0.047)。在73例IGF-1升高的患者中,55例(75.3%)IGF-1随时间自发正常化。最终身高SDS校正目标身高SDS与IGF-1升高无关(P = .113)。在肿瘤进展的数量上没有发现差异。结论:IGF-1浓度升高常见于鞍上性LGG患儿,尤其是年龄较小的患儿、NF1突变患儿或体重过轻患儿。IGF-1的升高可以随着时间的推移而消退,对最终身高或肿瘤进展没有影响似乎令人放心。
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来源期刊
European Journal of Endocrinology
European Journal of Endocrinology 医学-内分泌学与代谢
CiteScore
9.80
自引率
3.40%
发文量
354
审稿时长
1 months
期刊介绍: European Journal of Endocrinology is the official journal of the European Society of Endocrinology. Its predecessor journal is Acta Endocrinologica. The journal publishes high-quality original clinical and translational research papers and reviews in paediatric and adult endocrinology, as well as clinical practice guidelines, position statements and debates. Case reports will only be considered if they represent exceptional insights or advances in clinical endocrinology. Topics covered include, but are not limited to, Adrenal and Steroid, Bone and Mineral Metabolism, Hormones and Cancer, Pituitary and Hypothalamus, Thyroid and Reproduction. In the field of Diabetes, Obesity and Metabolism we welcome manuscripts addressing endocrine mechanisms of disease and its complications, management of obesity/diabetes in the context of other endocrine conditions, or aspects of complex disease management. Reports may encompass natural history studies, mechanistic studies, or clinical trials. Equal consideration is given to all manuscripts in English from any country.
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