{"title":"Gestational Trophoblastic Disease: A Clinical Review and Case Study Presentation for the Advanced Practice Nurse.","authors":"Merlendi Brown","doi":"10.1188/25.CJON.E97-E102","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Gestational trophoblastic (GT) disease is a continuum of gynecologic disorders that begins with a hydatidiform mole and may progress to GT neoplasia.</p><p><strong>Objectives: </strong>The purpose of this article is to review the pathophysiology and clinical manifestations associated with GT disease and provide the advanced practice RN with evidence-based management strategies to use when caring for patients.</p><p><strong>Methods: </strong>A case study details a woman aged 42 years with a hydatidiform mole who underwent multiple uterine curettage procedures. The disease progressed to GT neoplasia, characterized by elevated human chorionic gonadotropin (hCG) levels. The patient completed a 10-week course of IV methotrexate, and hCG levels returned to normal range.</p><p><strong>Findings: </strong>Serial monitoring of hCG levels is paramount when caring for a patient with GT disease. The advanced practice RN should recognize the pathologic significance of rising hCG levels, report these trends to the treating physician, and aim to improve health outcomes.</p>","PeriodicalId":10350,"journal":{"name":"Clinical journal of oncology nursing","volume":"29 3","pages":"E97-E102"},"PeriodicalIF":1.3000,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12124881/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical journal of oncology nursing","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1188/25.CJON.E97-E102","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NURSING","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Gestational trophoblastic (GT) disease is a continuum of gynecologic disorders that begins with a hydatidiform mole and may progress to GT neoplasia.
Objectives: The purpose of this article is to review the pathophysiology and clinical manifestations associated with GT disease and provide the advanced practice RN with evidence-based management strategies to use when caring for patients.
Methods: A case study details a woman aged 42 years with a hydatidiform mole who underwent multiple uterine curettage procedures. The disease progressed to GT neoplasia, characterized by elevated human chorionic gonadotropin (hCG) levels. The patient completed a 10-week course of IV methotrexate, and hCG levels returned to normal range.
Findings: Serial monitoring of hCG levels is paramount when caring for a patient with GT disease. The advanced practice RN should recognize the pathologic significance of rising hCG levels, report these trends to the treating physician, and aim to improve health outcomes.
期刊介绍：
The Clinical Journal of Oncology Nursing (CJON) is an official publication of the Oncology Nursing Society (ONS) and is directed to the practicing nurse specializing in the care of patients with an actual or potential diagnosis of cancer. CJON is a vehicle to promote the mission of ONS, which is to advance excellence in oncology nursing and quality cancer care. The CJON mission is twofold: to provide practical information necessary to care for patients and their families across the cancer continuum and to develop publication skills in oncology nurses.
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