Distal anastomotic new entry tears predict long-term outcomes after hemi-arch repair for DeBakey I aortic dissection†.

Prabhvir S Marway, Carlos A Campello Jorge, Rana-Armaghan Ahmad, Nicasius Tjahjadi, Himanshu J Patel, Bo Yang, Nicholas S Burris
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Abstract

Objectives: Aortic arch tears, including distal anastomosis new entry tears and residual arch tears, have been associated with adverse outcomes (false lumen growth, distal reoperation) after hemi-arch repair for DeBakey Type I aortic dissection. However, no study has compared distal anastomosis new entry tears and RATs as independent entities despite their distinct aetiologies and preventative strategies which may inform surgical management.

Methods: Retrospective cohort study of adult patients with hemi-arch repair for DeBakey Type I aortic dissection at a tertiary referral centre (1996-2021). We included patients who survived beyond their initial hospitalization with good-quality post-operative CT angiograms. Distal anastomosis new entry tears and residual arch tears metrics were collected from the first good-quality post-operative CT. Maximal aortic diameters (distal to graft) were collected from pre- and post-hemi-arch repair CT angiograms. Presence and imaging characteristics of distal anastomosis new entry tears and RATs were examined for prediction of false lumen growth and distal aortic intervention.

Results: We included 272 patients, and 24.5% (69) had distal anastomosis new entry tears, which on multivariable analysis was associated with a post-operative descending diameter change of +6.2 mm (95% confidence interval [CI]: 4.5, 7.9) and greater risk of distal intervention, hazard ratio 3.24 (95% CI: 1.57, 6.68); residual arch tears were not significantly associated, hazard ratio 0.72 (95% CI: 0.28, 1.83). Distal anastomosis new entry tears located on the greater curvature versus lesser curvature (58% vs 42%, P = 0.044) were more likely to lead to reoperation (45% vs 17%, P = 0.033).

Conclusions: Distal anastomosis new entry tears, not residual arch tears, correlate strongly with negative descending aorta remodelling and distal intervention after hemi-arch repair for DeBakey I aortic dissection. Therefore, additional strategies are warranted to prevent distal anastomosis new entry tears, a result of anastomotic technical challenge, during operative repair.

远端吻合口新入口撕裂预测DeBakey I型主动脉夹层半弓修复术后的长期预后。
目的:DeBakey I型主动脉夹层半弓修复术后,主动脉弓撕裂,包括远端吻合口新入口撕裂和残余弓撕裂,与不良后果(假腔生长,远端再手术)相关。然而,没有研究将远端吻合口新入口撕裂和大鼠作为独立的实体进行比较,尽管它们的病因和预防策略不同,这可能为外科治疗提供信息。方法:回顾性队列研究在三级转诊中心对DeBakey I型主动脉夹层半弓修复的成年患者(1996-2021)。我们纳入了术后CT血管造影质量良好的初次住院后存活的患者。远端吻合口新入口撕裂和残余弓撕裂指标由术后第一次高质量CT采集。从半弓修复前和半弓修复后的CT血管造影中收集最大主动脉直径(移植物远端)。检查远端吻合口新入口撕裂和大鼠的存在和影像学特征,以预测假腔生长和远端主动脉介入。结果:我们纳入了272例患者,其中24.5%(69例)有远端吻合口新入口撕裂,多变量分析显示,术后降径变化+ 6.2 mm(95%可信区间:4.5,7.9),远端干预风险更高,风险比3.24 (95% CI: 1.57, 6.68);残弓撕裂无显著相关,风险比0.72 (95% CI: 0.28, 1.83)。远端吻合口新入口裂口位于大弯曲处比小弯曲处(58%比42%,p = 0.044)更容易导致再手术(45%比17%,p = 0.033)。结论:DeBakey I型主动脉夹层半弓修复术后,远端吻合口新入口撕裂与负性降主动脉重构及远端干预密切相关,而非残余弓撕裂。因此,在手术修复过程中,有必要采取其他策略来防止远端吻合口新入口撕裂,这是吻合口技术挑战的结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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