Agreement between early-phase amyloid-PET and pulsed arterial spin labeling in a memory clinic cohort.

IF 4.8 3区 医学 Q1 GENETICS & HEREDITY
F Ribaldi, A J Mendes, I Boscolo Galazzo, V Natale, G Mathoux, M Pievani, K O Lovblad, M Scheffler, G B Frisoni, V Garibotto, F B Pizzini
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引用次数: 0

Abstract

Relative cerebral blood flow (rCBF), assessed using pulsed arterial spin labeling (pASL) MRI, and the standardized uptake value ratio (SUVr) in early-phase amyloid-PET (ePET) are used as proxies for brain perfusion. These methods have the potential to streamline clinical workflows and reduce the burden on patients by eliminating the need for additional procedures. While both techniques have shown good agreement with the gold standard for glucose metabolism assessment, F-fluorodeoxyglucose-PET, a direct comparison between them has yet to be fully clarified. This retrospective study aimed to compare perfusion-like data from pASL (rCBF) and ePET (SUVr) in a memory clinic cohort. We included 46 subjects (69 ± 8 years; 37 women) from the Geneva Memory Center (cognitively impaired-CI n = 29; cognitively unimpaired-CU n = 17), with available pASL and ePET. We evaluated the association between rCBF and SUVr values across 18 cortical and subcortical regions using linear regression and the within-subject coefficient of variation (wsCV). Regional differences between CU and CI groups were assessed using linear regression model corrected for age. We observed significant association between rCBF and SUVr in precuneus (β = 0.69, wsCV = 16.9), angular gyrus (β = 0.64, wsCV = 19.4), and hippocampus (β = 0.23, wsCV = 16.1). Additionally, significant differences in rCBF between CU and CI were also observed in the posterior cingulate, precuneus, calcarine, hippocampus, and composite (p < 0.05), while SUVr showed significant differences only in the hippocampus. Our findings indicate weak to moderate local correlations between the two techniques. However, both exhibited differing regional perfusion levels in CU and CI groups, with rCBF showing more regional differences between cognitive stages in comparison with SUVr. KEY MESSAGES: rCBF is assessed through pASL MRI and SUVr through ePET, both serving as proxies of brain perfusion. Weak to moderate associations between rCBF and SUVr were found in a number of brain regions. rCBF and SUVr differences between cognitive stages were observed mostly in cortical and subcortical regions respectively. Both techniques were able to identify AD perfusion-like differences expected in cognitively impaired vs unimpaired.

早期淀粉样蛋白pet和脉冲动脉自旋标记在记忆临床队列中的一致性。
使用脉冲动脉自旋标记(pASL) MRI评估的相对脑血流量(rCBF)和早期淀粉样蛋白pet (ePET)的标准化摄取值比(SUVr)被用作脑灌注的替代指标。这些方法有可能简化临床工作流程,并通过消除对额外程序的需要来减轻患者的负担。虽然这两种技术都与葡萄糖代谢评估的金标准f -氟脱氧葡萄糖- pet表现出良好的一致性,但它们之间的直接比较尚未得到充分澄清。本回顾性研究旨在比较记忆临床队列中pASL (rCBF)和ePET (SUVr)的灌注样数据。我们纳入46名受试者(69±8岁;来自日内瓦记忆中心的37名女性)(认知障碍- ci n = 29;认知未受损- cu n = 17),具有可用的pASL和ePET。我们使用线性回归和受试者内变异系数(wsCV)评估了18个皮质和皮质下区域的rCBF和SUVr值之间的关系。使用校正年龄的线性回归模型评估CU组和CI组之间的区域差异。我们观察到rCBF与楔前叶(β = 0.69, wsCV = 16.9)、角回(β = 0.64, wsCV = 19.4)和海马(β = 0.23, wsCV = 16.1)的SUVr有显著相关性。此外,CU和CI之间的rCBF在扣带后、楔前叶、钙碱、海马和复合(p . 1)中也观察到显著差异
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来源期刊
Journal of Molecular Medicine-Jmm
Journal of Molecular Medicine-Jmm 医学-医学:研究与实验
CiteScore
9.30
自引率
0.00%
发文量
100
审稿时长
1.3 months
期刊介绍: The Journal of Molecular Medicine publishes original research articles and review articles that range from basic findings in mechanisms of disease pathogenesis to therapy. The focus includes all human diseases, including but not limited to: Aging, angiogenesis, autoimmune diseases as well as other inflammatory diseases, cancer, cardiovascular diseases, development and differentiation, endocrinology, gastrointestinal diseases and hepatology, genetics and epigenetics, hematology, hypoxia research, immunology, infectious diseases, metabolic disorders, neuroscience of diseases, -omics based disease research, regenerative medicine, and stem cell research. Studies solely based on cell lines will not be considered. Studies that are based on model organisms will be considered as long as they are directly relevant to human disease.
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