Measuring Postpartum Milk Production Following Antenatal Milk Expression in Mothers of Infants With Congenital Anomalies.

IF 1.6 4区医学 Q2 NURSING

Advances in Neonatal Care Pub Date : 2025-06-01 Epub Date: 2025-05-20 DOI:10.1097/ANC.0000000000001270

Nina A Juntereal, Ching T Lai, Donna T Geddes, Eileen T Lake, Diane L Spatz

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Abstract

Background: Mothers of infants with congenital anomalies may experience challenges with milk production. Antenatal milk expression (AME) is thought to support milk production, as past research suggests it facilitates secretory activation. However, past research relied on self-reported data.

Purpose: This study examined secretory activation and coming to volume, 2 critical stages of postpartum milk production, by measurement of human milk biomarkers from days 1 to 7 and 24-hour milk volume from birth until day 14 in mothers of infants with congenital anomalies who practiced AME.

Methods: Women carrying infants with congenital anomalies received AME education, did AME, gave birth, and recorded their 24-hour pumping frequency and milk volume. An ion selective electrode (ISE) and laboratory analysis were used to measure human milk biomarkers.

Results: Sixteen mothers completed AME, and all infants were born at term. Most mothers (87.5%) had normal biomarkers at least once, but biomarkers did not stay in normal range. Four mothers (25%) experienced secretory activation within 72 hours after birth. The pumping frequency and 24-hour milk volume varied. Only 9 (56.25%) mothers secreted ≥500 mL of milk by day 14.

Implications for practice: AME may offer benefits, but secretory activation does not appear to be impacted. The ISE shows promise as a nursing-driven intervention to screen for potential milk volume concerns.

Implications for research: Further research is needed on AME and human milk biomarkers in this at-risk population.

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先天性异常婴儿母亲在产前母乳表达后测量产后产奶量。

背景：患有先天性畸形婴儿的母亲可能会遇到产奶困难。产前乳汁表达（AME）被认为支持产奶量，因为过去的研究表明它促进分泌激活。然而，过去的研究依赖于自我报告的数据。目的：本研究通过测量患有先天性畸形婴儿的母亲从出生第1天到第7天的母乳生物标志物和从出生到第14天的24小时奶量，研究了分泌激活和产后产奶的两个关键阶段。方法：对携带先天性异常婴儿的产妇进行AME教育、AME治疗、分娩，记录其24小时抽吸次数和泌乳量。使用离子选择电极（ISE）和实验室分析来测量人乳生物标志物。结果：16名母亲完成了AME，所有婴儿均足月出生。大多数母亲（87.5%）至少有一次生物标志物正常，但生物标志物并未保持在正常范围内。四名母亲（25%）在出生后72小时内出现分泌激活。吸乳频率和24小时泌乳量各不相同。只有9位（56.25%）母亲在第14天分泌≥500 mL乳汁。对实践的启示：AME可能提供益处，但分泌激活似乎不受影响。ISE显示了作为一种护理驱动的干预措施来筛选潜在的乳汁量问题的希望。研究意义：需要在这一高危人群中进一步研究AME和人乳生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in Neonatal Care NURSING-

CiteScore

2.60

自引率

5.90%

发文量

101

期刊介绍： Advances in Neonatal Care takes a unique and dynamic approach to the original research and clinical practice articles it publishes. Addressing the practice challenges faced every day—caring for the 40,000-plus low-birth-weight infants in Level II and Level III NICUs each year—the journal promotes evidence-based care and improved outcomes for the tiniest patients and their families. Peer-reviewed editorial includes unique and detailed visual and teaching aids, such as Family Teaching Toolbox, Research to Practice, Cultivating Clinical Expertise, and Online Features. Each issue offers Continuing Education (CE) articles in both print and online formats.