Preparation and Characterization of Nanoparticles for the Controlled Release of the Endocannabinoid 2-Arachidonoylglycerol (2-AG).

Q4 Biochemistry, Genetics and Molecular Biology

Methods in molecular biology Pub Date : 2025-05-22 DOI:10.1007/7651_2025_636

Sevil Köse, Cem Varan, Tuba Reçber, Emirhan Nemutlu, Erem Bilensoy, Petek Korkusuz

引用次数: 0

Abstract

Nanoparticles containing endocannabinoid (2-arachidonoylglycerol, 2-AG) can serve as stable, long-lasting mobilization agents for hematopoietic cells. These polycaprolactone (PCL) nanoparticles are prepared using the emulsion evaporation method, and their physicochemical properties such as particle size, polydispersity index (PDI), zeta potential, encapsulation efficiency, and release profile, are characterized. Here, we describe the preparation and characterization methods for 2-AG-loaded PCL nanoparticles.

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内源性大麻素2-花生四烯醇甘油（2-AG）控释纳米颗粒的制备与表征

含有内源性大麻素（2-花生四烯醇甘油，2-AG）的纳米颗粒可以作为稳定、持久的造血细胞动员剂。采用乳液蒸发法制备了聚己内酯（PCL）纳米颗粒，并对其粒径、多分散性指数（PDI）、zeta电位、包封效率和释放特性等理化性质进行了表征。本文描述了负载2- ag的PCL纳米颗粒的制备和表征方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Methods in molecular biology Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

2.00

自引率

0.00%

发文量

3536

期刊介绍： For over 20 years, biological scientists have come to rely on the research protocols and methodologies in the critically acclaimed Methods in Molecular Biology series. The series was the first to introduce the step-by-step protocols approach that has become the standard in all biomedical protocol publishing. Each protocol is provided in readily-reproducible step-by-step fashion, opening with an introductory overview, a list of the materials and reagents needed to complete the experiment, and followed by a detailed procedure that is supported with a helpful notes section offering tips and tricks of the trade as well as troubleshooting advice.