Amar El Hamwi, Fanny Hamard, Charlotte Hinault-Boyer, Juliette Raffort, Fabien Lareyre, Jacques Grober, Damien Massalou
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引用次数: 0
Abstract
Background: Acute intestinal ischemia (AII) remains a major diagnostic challenge, associated with high morbidity and mortality. Current biomarkers lack sufficient sensitivity and specificity. Proglucagon-derived peptides constitute a family of hormones involved in the regulation of intestinal mucosal physiology. Alterations in circulating levels of these peptides may occur during intestinal ischemia, suggesting their potential as diagnostic biomarkers.
Objective: The aim of our study was to assess whether circulating levels of proglucagon-derived peptides differ between patients with acute intestinal ischemia and a control group.
Study design: This was a prospective, single-center study including patients diagnosed with acute intestinal ischemia (AII) and a control group of patients presenting with acute abdominal pain. Clinical and biochemical parameters, as well as management strategies, were recorded. Circulating levels of proglucagon-derived peptides were measured in serum.
Results: A total of 23 patients were included in the ischemia group and 23 in the control group. Univariate analysis revealed statistically significant differences between groups : GLP-1 (glucagon-like peptide 1) levels were significantly higher in the ischemia group compared to controls (5.3 pmol/L vs. 2.3 pmol/L, p = 0.01), as were GLP-2 (glucagon-like peptide 2) levels (2.8 pmol/L vs. 0.9 pmol/L, p = 0.023)and venous lactate (3.3 mmol/L vs. 1.6 mmol/L, p = 0.034). Other biomarkers, including glicentin, intestinal fatty acid-binding protein (I-FABP), and citrulline, showed borderline or non-significant differences.
Conclusion: Serum levels of GLP-1 and GLP-2 were significantly increased in patients with acute intestinal ischemia compared to controls. These findings suggest that GLP-1 and GLP-2 may serve as promising biomarkers for the early diagnosis of AII in the emergency setting.
期刊介绍：
The Journal of the American College of Surgeons (JACS) is a monthly journal publishing peer-reviewed original contributions on all aspects of surgery. These contributions include, but are not limited to, original clinical studies, review articles, and experimental investigations with clear clinical relevance. In general, case reports are not considered for publication. As the official scientific journal of the American College of Surgeons, JACS has the goal of providing its readership the highest quality rapid retrieval of information relevant to surgeons.
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