Significant Associations Between Blood Cell Counts and a Large Number of Salivary Cytokines, Chemokines, and Growth Factors.

IF 1.9 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Lars B Eriksson, Mats Eriksson, Torsten Gordh, Anders Larsson
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引用次数: 0

Abstract

The association between local oral inflammation and cardiovascular risk has been extensively studied, with results indicating a bidirectional relationship. The aim of the present study was to investigate the associations between blood cells and a large number of salivary cytokines, chemokines, and growth factors. The study consisted of 165 individuals who were referred to the Oral and Maxillofacial Surgery clinic at Falun County hospital, Sweden, for surgical removal of impacted lower third molar. The study subjects did not have any known inflammatory disorders. Complete blood cell counts were analyzed using the routine laboratory at Falun Hospital, Falun, Sweden. Proteomic analysis of 92 inflammation-related protein biomarkers in saliva was performed using a multiplex proximity extension assay. After adjustment for multiplicity testing using the false discovery rate approach, there remained significant association between several saliva cytokines, chemokines, and growth factors and white blood cell counts (n = 19), neutrophil counts (n = 18), erythrocyte counts (n = 13), hemoglobin concentrations (n = 20), erythrocyte volume fractions (n = 22), and platelet counts (n = 12). There are several significant associations between local inflammatory cytokines in the oral cavity and blood cell parameters indicating a relationship between local and systemic inflammatory activity.

血细胞计数与大量唾液细胞因子、趋化因子和生长因子之间的显著关联。
局部口腔炎症与心血管风险之间的关系已被广泛研究,结果表明存在双向关系。本研究的目的是研究血细胞与大量唾液细胞因子、趋化因子和生长因子之间的关系。该研究包括165名患者,他们被转诊到瑞典法轮县医院的口腔颌面外科诊所,接受手术切除阻生的下第三磨牙。研究对象没有任何已知的炎症性疾病。全血细胞计数在瑞典法轮医院的常规实验室进行分析。使用多重接近扩展法对唾液中92种炎症相关蛋白生物标志物进行蛋白质组学分析。在使用错误发现率方法调整多重性测试后,几种唾液细胞因子、趋化因子和生长因子与白细胞计数(n = 19)、中性粒细胞计数(n = 18)、红细胞计数(n = 13)、血红蛋白浓度(n = 20)、红细胞体积分数(n = 22)和血小板计数(n = 12)之间仍然存在显著关联。口腔局部炎症细胞因子与血细胞参数之间存在一些显著关联,表明局部和全身炎症活动之间存在关系。
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来源期刊
CiteScore
3.80
自引率
0.00%
发文量
78
审稿时长
2.2 months
期刊介绍: Journal of Interferon & Cytokine Research (JICR) provides the latest groundbreaking research on all aspects of IFNs and cytokines. The Journal delivers current findings on emerging topics in this niche community, including the role of IFNs in the therapy of diseases such as multiple sclerosis, the understanding of the third class of IFNs, and the identification and function of IFN-inducible genes.
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