The latest advances with natural products in drug discovery and opportunities for the future: a 2025 update.

IF 6 2区医学 Q1 PHARMACOLOGY & PHARMACY

Expert Opinion on Drug Discovery Pub Date : 2025-06-05 DOI:10.1080/17460441.2025.2507382

Shaowen Xie, Fangyi Zhan, Jingjie Zhu, Shengtao Xu, Jinyi Xu

{"title":"The latest advances with natural products in drug discovery and opportunities for the future: a 2025 update.","authors":"Shaowen Xie, Fangyi Zhan, Jingjie Zhu, Shengtao Xu, Jinyi Xu","doi":"10.1080/17460441.2025.2507382","DOIUrl":null,"url":null,"abstract":"Introduction: The landscape of drug discovery is rapidly evolving, with natural products (NPs) playing a pivotal role in the development of novel therapeutics. Despite their historical significance, challenges persist in fully harnessing their potential in the development of modern medicine.Areas covered: This perspective discusses the recent advances and opportunities in NP-based drug discovery. This includes exploration of the recently approved representative NP-derived drugs, innovative target identification strategies and advancements in hybrid NP molecules for addressing complex diseases. Moreover, the authors also discuss the role of NP-derived payloads in antibody-drug conjugates (ADCs) for targeted cancer therapy. This article is based on searches using the FDA and DrugBank database as well the Derwent Innovations Index from Web of Science between the period of 2017 to 2025.Expert opinion: NPs remain vital to drug discovery, demonstrating adaptability in tackling complex medical challenges. Future efforts should focus on integrating advanced methodologies, such as artificial intelligence (AI), high-throughput screening, chemical biology, bioinformatics, gene regulation, the highly accurate non-labeling chemical proteomics approach to explore novel NPs targets. Emphasizing these developments will be crucial for maximizing the therapeutic potential of NPs in combating unmet medical needs.","PeriodicalId":12267,"journal":{"name":"Expert Opinion on Drug Discovery","volume":" ","pages":"1-17"},"PeriodicalIF":6.0000,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Expert Opinion on Drug Discovery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/17460441.2025.2507382","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: The landscape of drug discovery is rapidly evolving, with natural products (NPs) playing a pivotal role in the development of novel therapeutics. Despite their historical significance, challenges persist in fully harnessing their potential in the development of modern medicine.

Areas covered: This perspective discusses the recent advances and opportunities in NP-based drug discovery. This includes exploration of the recently approved representative NP-derived drugs, innovative target identification strategies and advancements in hybrid NP molecules for addressing complex diseases. Moreover, the authors also discuss the role of NP-derived payloads in antibody-drug conjugates (ADCs) for targeted cancer therapy. This article is based on searches using the FDA and DrugBank database as well the Derwent Innovations Index from Web of Science between the period of 2017 to 2025.

Expert opinion: NPs remain vital to drug discovery, demonstrating adaptability in tackling complex medical challenges. Future efforts should focus on integrating advanced methodologies, such as artificial intelligence (AI), high-throughput screening, chemical biology, bioinformatics, gene regulation, the highly accurate non-labeling chemical proteomics approach to explore novel NPs targets. Emphasizing these developments will be crucial for maximizing the therapeutic potential of NPs in combating unmet medical needs.

查看原文本刊更多论文

天然产物在药物发现和未来机遇方面的最新进展：2025年更新。

药物发现的前景正在迅速发展，天然产物（NPs）在新疗法的发展中起着关键作用。尽管它们具有重要的历史意义，但在充分利用它们在现代医学发展中的潜力方面仍然存在挑战。涵盖领域：这一视角讨论了基于np的药物发现的最新进展和机遇。这包括探索最近批准的具有代表性的NP衍生药物，创新的靶标识别策略以及用于治疗复杂疾病的混合NP分子的进展。此外，作者还讨论了np衍生的有效载荷在靶向癌症治疗的抗体-药物偶联物（adc）中的作用。本文基于2017年至2025年期间对FDA和DrugBank数据库以及Web of Science的Derwent创新指数的搜索。专家意见：np对药物发现仍然至关重要，在应对复杂的医疗挑战方面表现出适应性。未来的工作应该集中在整合先进的方法，如人工智能（AI），高通量筛选，化学生物学，生物信息学，基因调控，高精度的非标记化学蛋白质组学方法，以探索新的NPs靶点。强调这些发展对于最大限度地发挥NPs在解决未满足的医疗需求方面的治疗潜力至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Expert Opinion on Drug Discovery 医学-药学

CiteScore

10.20

自引率

1.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Expert Opinion on Drug Discovery (ISSN 1746-0441 [print], 1746-045X [electronic]) is a MEDLINE-indexed, peer-reviewed, international journal publishing review articles on novel technologies involved in the drug discovery process, leading to new leads and reduced attrition rates. Each article is structured to incorporate the author’s own expert opinion on the scope for future development. The Editors welcome: Reviews covering chemoinformatics; bioinformatics; assay development; novel screening technologies; in vitro/in vivo models; structure-based drug design; systems biology Drug Case Histories examining the steps involved in the preclinical and clinical development of a particular drug The audience consists of scientists and managers in the healthcare and pharmaceutical industry, academic pharmaceutical scientists and other closely related professionals looking to enhance the success of their drug candidates through optimisation at the preclinical level.