Effects of chronic kidney disease-associated pruritus on quality of life in hemodialysis and non-dialysis patients: A cross-sectional study.

IF 1.1 4区医学 Q3 UROLOGY & NEPHROLOGY

Clinical nephrology Pub Date : 2025-05-21 DOI:10.5414/CN111649

Abdullah Ucar, Mevlut Tamer Dincer, Safak Mirioglu, Siddik Keskin, Cebrail Karaca

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引用次数: 0

Abstract

Aims: Chronic kidney disease-associated pruritus (CKD-aP) is a common and distressing symptom, particularly in hemodialysis (HD) patients, significantly impacting their quality of life. This study aimed to investigate the effects of CKD-aP frequency and severity on quality of life in both HD and non-HD stage 3 - 5 CKD patients.

Materials and methods: This cross-sectional case-control study was conducted from January to May 2024. Pruritus was assessed using the 5-D itch scale, and quality of life was evaluated with the World Health Organization Quality of Life Scale-Short Form (WHOQoL-BREF) questionnaire. Correlations between pruritus severity and patient characteristics were analyzed.

Results: The study involved 169 patients, comprising 80 non-HD stage 3 - 5 CKD patients and 89 HD patients, with a mean age of 55.2 ± 16.7 years. Pruritus was significantly more prevalent in the HD group than in the non-HD group (61.8 vs. 41.3%, p = 0.008). HD patients had more pruritic body areas and higher 5-D itch scale scores (0 (0 - 8.5) vs. 0 (0 - 3.75), p = 0.002; 9.3 (8.0 - 14.8) vs. 8.0 (8.0 - 10.3), p = 0.003). In the HD group, pruritus was associated with lower quality of life in the psychological health, social relationships, and environment domains of the WHOQoL-BREF questionnaire (50.0 (35.4 - 58.3)% vs. 54.2 (42.7 - 66.7)%, p = 0.027; 50.0 (33.3 - 58.3)% vs. 50.0 (41.6 - 66.7)%, p = 0.046; 53.1 (40.6 - 65.5)% vs. 56.3 (50.0 - 68.8)%, p = 0.026, respectively). Pruritus also correlated with lower hemoglobin levels, higher serum creatinine levels, and poorer overall quality of life in both groups, with female sex and erythropoiesis-stimulating agent use as significant contributing factors.

Conclusion: Pruritus significantly impairs the quality of life in HD patients.

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慢性肾脏疾病相关性瘙痒对血液透析和非透析患者生活质量的影响：一项横断面研究

目的：慢性肾脏疾病相关性瘙痒（CKD-aP）是一种常见且令人痛苦的症状，特别是在血液透析（HD）患者中，显著影响他们的生活质量。本研究旨在探讨CKD- ap频率和严重程度对HD和非HD 3 - 5期CKD患者生活质量的影响。材料与方法：本研究于2024年1 - 5月进行横断面病例对照研究。采用5维瘙痒量表评估瘙痒，采用世界卫生组织生活质量量表-短表（WHOQoL-BREF）问卷评估生活质量。分析瘙痒严重程度与患者特征的相关性。结果：本研究共纳入169例患者，其中非HD 3 - 5期CKD患者80例，HD患者89例，平均年龄55.2±16.7岁。瘙痒症在HD组的发生率明显高于非HD组（61.8% vs 41.3%, p = 0.008）。HD患者瘙痒体区较多，5-D瘙痒评分较高(0 (0 - 8.5)vs. 0 (0 - 3.75), p = 0.002；9.3(8.0 - 14.8)和8.0 (8.0 - 10.3),p = 0.003)。在HD组中，瘙痒与WHOQoL-BREF问卷心理健康、社会关系和环境领域较低的生活质量相关(50.0 (35.4 - 58.3)% vs. 54.2 (42.7 - 66.7)%, p = 0.027；50.0(33.3 - 58.3) %与50.0 (41.6 - 66.7)%,p = 0.046;53.1(40.6 - 65.5) %与56.3(50.0 - 68.8)%,分别为p = 0.026)。瘙痒症还与两组血红蛋白水平较低、血清肌酐水平较高和整体生活质量较差相关，其中女性和使用促红细胞生成素是重要的影响因素。结论：瘙痒严重影响HD患者的生活质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical nephrology 医学-泌尿学与肾脏学

CiteScore

2.10

自引率

9.10%

发文量

138

审稿时长

4-8 weeks

期刊介绍： Clinical Nephrology appears monthly and publishes manuscripts containing original material with emphasis on the following topics: prophylaxis, pathophysiology, immunology, diagnosis, therapy, experimental approaches and dialysis and transplantation.