CAR-NK cells for haematological cancers

IF 2 4区医学 Q3 HEMATOLOGY

Best Practice & Research Clinical Haematology Pub Date : 2025-05-15 DOI:10.1016/j.beha.2025.101631

Mohammadamin Noorafrooz , Robert Peter Gale , Ramin Noorafrooz , Sanaz Ghods

引用次数: 0

Abstract

Chimeric antigen receptor-natural-killer (CAR-NK)-cells are a promising cancer cell therapy. Several features of CAR-NK-cells are suggesting an advantage over CAR-T-cells such as less complex manufacturing, “off-the-shelf” use and lower risks of cytokine release (CRS) and immune effector cell-associated neurotoxicity syndromes (ICANS). CAR-NK-cells derived from several sources are associated with promising pre-clinical and clinical results in haematological cancers. We comprehensively discuss the current landscape of CAR-NK-cell therapy in haematological cancers emphasizing recent progress and future directions. Additionally, we explore the biological mechanisms, engineering and sources of CAR-NK-cells. CAR-NK-cell therapy offers a safe, accessible and efficient option for haematological cancers.

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CAR-NK细胞用于血液学癌症

嵌合抗原受体-自然杀伤细胞（CAR-NK）是一种很有前途的肿瘤细胞治疗方法。car - nk细胞的几个特征表明它比car -t细胞有优势，如制造过程更简单、“现成”使用、细胞因子释放（CRS）和免疫效应细胞相关神经毒性综合征（ICANS）的风险更低。来自多种来源的car - nk细胞与血液学癌症的临床前和临床结果有关。我们全面讨论了car - nk细胞治疗血液病癌症的现状，强调了最近的进展和未来的方向。此外，我们还探讨了car - nk细胞的生物学机制、工程和来源。car - nk细胞疗法为血液学癌症提供了一种安全、可及和有效的治疗选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Best Practice & Research Clinical Haematology 医学-血液学

CiteScore

4.20

自引率

0.00%

发文量

审稿时长

35 days

期刊介绍： Best Practice & Research Clinical Haematology publishes review articles integrating the results from the latest original research articles into practical, evidence-based review articles. These articles seek to address the key clinical issues of diagnosis, treatment and patient management. Each issue follows a problem-orientated approach which focuses on the key questions to be addressed, clearly defining what is known and not known, covering the spectrum of clinical and laboratory haematological practice and research. Although most reviews are invited, the Editor welcomes suggestions from potential authors.