{"title":"The event-related potential components across psychiatric disorders: a systematic review and network meta-analysis","authors":"Zhe Lu, Jing Guo, Junyuan Sun, Yaoyao Sun, Ying Zhang, Yuyanan Zhang, Yundan Liao, Zhewei Kang, Xiaoyang Feng, Guorui Zhao, Rui Yuan, Yunqing Zhu, Weihua Yue","doi":"10.1038/s41380-025-03062-5","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Objective</h3><p>This study aims to compare and rank event-related potentials (ERP) components among healthy individuals and patients with various psychiatric disorders, including schizophrenia (SCZ), bipolar disorder (BD), major depressive disorder (MDD), anxiety disorder (AD), and obsessive-compulsive disorder (OCD).</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>A comprehensive search was conducted in PubMed, Embase, PsycINFO, and Web of Science up to March 20th, 2024. Original studies reporting ERP component data in patients with psychiatric disorders were included. Network meta-analyses were conducted to compare ERP components, including P300, mismatch negative (MMN), P50, N1, N2, P1, and P2.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>From 47,391 citations, 687 studies were included, with sample sizes ranging from 893 to 16,879. Compared to healthy controls (HC), significant reduction in amplitudes and latency delay of P300, and reduced MMN amplitude were observed in SCZ, BD, and MDD. Additionally, SCZ displayed significant abnormalities in all P50 components. Reductions in N1, N2, and P2 amplitudes were noted in SCZ, with increased N2 latencies in SCZ and BD. The most significant difference across psychosis in EPR components was the MMN amplitude and ERN amplitude between OCD and SCZ. Finally, the composite ERP-score suggested SCZ rank the first in ERP abnormalities. Most primary outcomes were stable in sensitivity analyses.</p><h3 data-test=\"abstract-sub-heading\">Conclution</h3><p>The findings suggested that SCZ exhibited pronounced electrophysiological abnormalities, particularly in the P300 and P50 components. Moreover, the results provided a comprehensive overview of the varying electrophysiological profiles across different psychoses. These insights support the potential of ERPs as neurophysiological markers reflecting the neural dysfunctions associated with these disorders. Prospero registration: CRD42022361158</p>","PeriodicalId":19008,"journal":{"name":"Molecular Psychiatry","volume":"236 1","pages":""},"PeriodicalIF":9.6000,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Psychiatry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41380-025-03062-5","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Objective
This study aims to compare and rank event-related potentials (ERP) components among healthy individuals and patients with various psychiatric disorders, including schizophrenia (SCZ), bipolar disorder (BD), major depressive disorder (MDD), anxiety disorder (AD), and obsessive-compulsive disorder (OCD).
Methods
A comprehensive search was conducted in PubMed, Embase, PsycINFO, and Web of Science up to March 20th, 2024. Original studies reporting ERP component data in patients with psychiatric disorders were included. Network meta-analyses were conducted to compare ERP components, including P300, mismatch negative (MMN), P50, N1, N2, P1, and P2.
Results
From 47,391 citations, 687 studies were included, with sample sizes ranging from 893 to 16,879. Compared to healthy controls (HC), significant reduction in amplitudes and latency delay of P300, and reduced MMN amplitude were observed in SCZ, BD, and MDD. Additionally, SCZ displayed significant abnormalities in all P50 components. Reductions in N1, N2, and P2 amplitudes were noted in SCZ, with increased N2 latencies in SCZ and BD. The most significant difference across psychosis in EPR components was the MMN amplitude and ERN amplitude between OCD and SCZ. Finally, the composite ERP-score suggested SCZ rank the first in ERP abnormalities. Most primary outcomes were stable in sensitivity analyses.
Conclution
The findings suggested that SCZ exhibited pronounced electrophysiological abnormalities, particularly in the P300 and P50 components. Moreover, the results provided a comprehensive overview of the varying electrophysiological profiles across different psychoses. These insights support the potential of ERPs as neurophysiological markers reflecting the neural dysfunctions associated with these disorders. Prospero registration: CRD42022361158
目的对精神分裂症（SCZ）、双相情感障碍（BD）、重度抑郁障碍（MDD）、焦虑障碍（AD）和强迫症（OCD）患者和健康个体的事件相关电位（ERP）成分进行比较和排序。方法综合检索截至2024年3月20日的PubMed、Embase、PsycINFO、Web of Science。纳入了报告精神障碍患者ERP成分数据的原始研究。网络荟萃分析比较ERP组成，包括P300、错配负（MMN）、P50、N1、N2、P1和P2。结果共纳入47,391次引用，687项研究，样本量为893 ~ 16,879。与健康对照（HC）相比，SCZ、BD和MDD患者的P300波幅和潜伏期显著降低，MMN波幅也显著降低。此外，SCZ在所有P50成分中均表现出显著异常。SCZ的N1、N2和P2波幅减少，SCZ和BD的N2潜伏期增加。EPR成分在精神病中最显著的差异是强迫症和SCZ之间的MMN波幅和ERN波幅。最后，综合ERP评分显示SCZ在ERP异常中排名第一。在敏感性分析中，大多数主要结局是稳定的。结论SCZ表现出明显的电生理异常，尤其是P300和P50成分。此外，研究结果提供了不同精神病患者不同电生理特征的全面概述。这些见解支持erp作为反映与这些疾病相关的神经功能障碍的神经生理标志物的潜力。普洛斯彼罗注册：CRD42022361158
期刊介绍：
Molecular Psychiatry focuses on publishing research that aims to uncover the biological mechanisms behind psychiatric disorders and their treatment. The journal emphasizes studies that bridge pre-clinical and clinical research, covering cellular, molecular, integrative, clinical, imaging, and psychopharmacology levels.
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