Moderate Impairment in Binocular Contrast Sensitivity Predicts Faster Mobility Decline in Cognitively Unimpaired Older Adults

IF 4.5 2区医学 Q1 GERIATRICS & GERONTOLOGY

Journal of the American Geriatrics Society Pub Date : 2025-05-20 DOI:10.1111/jgs.19526

Ashley Wells, Michael E. Miller, Haiying Chen, Paul J. Laurienti, Stephen B. Kritchevsky, Atalie C. Thompson

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引用次数: 0

Abstract

Background

Impaired contrast sensitivity (CS) commonly occurs in older adults but has been largely overlooked as a contributing factor to functional impairment and decline. We examined if CS impairment predicts decline in performance on the expanded short physical performance battery (eSPPB) over 30 months of follow-up in cognitively healthy older adults.

Methods

Single center prospective cohort study of 192 cognitively unimpaired older adults with good visual acuity and self-reported visual function. Linear mixed models examined the difference in the association of moderately impaired baseline CS (logCS < 1.55) with performance on the eSPPB and its components–balance, 4 m gait speed, narrow walk, and chair pace–over 30 months. Multivariable models adjusted for the effect of age, race, and sex on the slopes over time.

Results

At baseline, the mean participant age was 76.5 ± 4.7 years, with 56.5% (N = 108) female and 9.4% (N = 18) black. Participants with moderately impaired CS at baseline had a significantly faster decline in eSPPB over a 30-month period (Beta: −0.115, 95% CI (−0.180, −0.050), p < 0.001) compared with those with normal CS (Beta: −0.022, 95% CI (−0.044, −0.001), p = 0.042). There was a difference in slopes of −0.093 units/year ((95% CI, −0.161, −0.024), p = 0.009) between groups. This difference in slopes remained significant after adjusting for the effect of age, sex, and race (difference in slopes −0.086, 95% CI (−0.155, −0.016), p = 0.016). Impaired CS predicted significantly greater declines in balance over 30 months (difference in slopes −3.512 (−6.826, −0.199), p = 0.0378), but the differences in gait speed, narrow walk, and chair pace were not significant.

Conclusions

In cognitively intact older adults with good visual acuity, moderately impaired CS was associated with a significantly faster decline in eSPPB, especially balance, over 30 months of follow-up. A relatively simple test of vision may identify a subset of older adults without cognitive dysfunction who are at risk for mobility decline.

查看原文本刊更多论文

双眼对比敏感度中度损伤预示着认知功能未受损的老年人活动能力下降更快。

背景：对比敏感性受损（CS）常见于老年人，但在很大程度上被忽视了作为功能损害和衰退的一个因素。我们对认知健康的老年人进行了为期30个月的随访，研究了CS损伤是否预示着扩展短时间物理性能电池（eSPPB）的性能下降。方法：采用单中心前瞻性队列研究，对192名视力良好、自述视力良好的认知功能正常的老年人进行研究。线性混合模型检验了中度受损基线CS相关性的差异(logCS结果：基线时，参与者的平均年龄为76.5±4.7岁，其中56.5% （N = 108）为女性，9.4% （N = 18）为黑人。基线时CS中度受损的参与者在30个月的时间内eSPPB的下降速度明显更快（Beta: -0.115, 95% CI (-0.180, -0.050), p）。结论：在30个月的随访中，在视力良好的认知完整的老年人中，CS中度受损与eSPPB的下降速度明显更快，特别是平衡。一项相对简单的视力测试可以识别出一部分没有认知功能障碍的老年人，他们有行动能力下降的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the American Geriatrics Society 医学-老年医学

CiteScore

10.00

自引率

6.30%

发文量

504

审稿时长

3-6 weeks

期刊介绍： Journal of the American Geriatrics Society (JAGS) is the go-to journal for clinical aging research. We provide a diverse, interprofessional community of healthcare professionals with the latest insights on geriatrics education, clinical practice, and public policy—all supporting the high-quality, person-centered care essential to our well-being as we age. Since the publication of our first edition in 1953, JAGS has remained one of the oldest and most impactful journals dedicated exclusively to gerontology and geriatrics.