Meeting report: DMDG peptide and oligonucleotide ADME workshop 2024.

IF 1.3 4区医学 Q4 PHARMACOLOGY & PHARMACY

Xenobiotica Pub Date : 2025-05-28 DOI:10.1080/00498254.2025.2506702

Inga Bjørnsdottir, Ralf Lotz, Bo Lindmark, Steve Hood, Jesper Kammersgaard Christensen

引用次数: 0

Abstract

1. Challenges within peptide and oligonucleotide ADME (absorption, distribution, metabolism and elimination) and scientific ideas on how to solve them were presented and discussed at the DMDG (Drug Metabolism and Discussion Group) Peptide and Oligonucleotide ADME Workshop 2024 (1^st September 2024). This meeting report summarises the presentations and discussions from this workshop.

2. The following topics were covered:Metabolism of conjugated peptides & proteinsStrategies for increased metabolic stability of peptidesIQ's take on metabolism & excretion studies for peptidesDMPK challenges related to oligonucleotides during developmentImaging of oligonucleotidesIdentification of extrahepatic targets of oligonucleotidesIn vitro systems for metabolism studies of oligonucleotidesNovel hybridisation LC-MS/MS approach for quantitative analysis of oligonucleotidesPKPD, PBPK & modelling.

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会议报告：DMDG肽和寡核苷酸ADME研讨会2024。

在2024年9月1日举行的DMDG（药物代谢和讨论组）肽和寡核苷酸ADME研讨会上，介绍和讨论了肽和寡核苷酸ADME（吸收、分布、代谢和消除）面临的挑战以及如何解决这些挑战的科学思路。本会议报告总结了本次研讨会的发言和讨论。会议涵盖了以下主题：偶联肽和蛋白质的代谢；提高肽代谢稳定性的策略；iq对肽代谢和排泄研究的研究；dmpk开发过程中与寡核苷酸相关的挑战；寡核苷酸的成像；寡核苷酸肝外靶点的鉴定；寡核苷酸代谢研究的体外系统；PBPK &建模。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Xenobiotica 医学-毒理学

CiteScore

3.80

自引率

5.60%

发文量

审稿时长

2 months

期刊介绍： Xenobiotica covers seven main areas, including:General Xenobiochemistry, including in vitro studies concerned with the metabolism, disposition and excretion of drugs, and other xenobiotics, as well as the structure, function and regulation of associated enzymesClinical Pharmacokinetics and Metabolism, covering the pharmacokinetics and absorption, distribution, metabolism and excretion of drugs and other xenobiotics in manAnimal Pharmacokinetics and Metabolism, covering the pharmacokinetics, and absorption, distribution, metabolism and excretion of drugs and other xenobiotics in animalsPharmacogenetics, defined as the identification and functional characterisation of polymorphic genes that encode xenobiotic metabolising enzymes and transporters that may result in altered enzymatic, cellular and clinical responses to xenobioticsMolecular Toxicology, concerning the mechanisms of toxicity and the study of toxicology of xenobiotics at the molecular levelXenobiotic Transporters, concerned with all aspects of the carrier proteins involved in the movement of xenobiotics into and out of cells, and their impact on pharmacokinetic behaviour in animals and manTopics in Xenobiochemistry, in the form of reviews and commentaries are primarily intended to be a critical analysis of the issue, wherein the author offers opinions on the relevance of data or of a particular experimental approach or methodology