The Real-World Prevalence of Esophagogastric Varices, Bleeding, Emergency Room Visits, and Hospitalization Among Patients with Advanced Hepatocellular Carcinoma in the United States: A Retrospective Cohort Study.

IF 4.2 3区 医学 Q2 ONCOLOGY
Journal of Hepatocellular Carcinoma Pub Date : 2025-05-15 eCollection Date: 2025-01-01 DOI:10.2147/JHC.S496618
Neehar D Parikh, Noh Jin Park, Michael Locker, Ishveen Chopra, Jason Yeaw, Shengsheng Yu
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Abstract

Purpose: Esophagogastric varices (EGV) and upper gastrointestinal bleeding are common and potentially fatal complications in patients with advanced hepatocellular carcinoma (aHCC). We aimed to evaluate the real-world prevalence of EGV among the aHCC population in the United States.

Patients and methods: This retrospective cohort study utilized IQVIA's PharMetrics Plus Health Plans Claims database between January 1, 2016, and July 31, 2021 (study period). Adult patients with an aHCC diagnosis who initiated systemic therapies were included, while those with any secondary malignancies or prior liver transplant at baseline were excluded. The date of therapy initiation was the index date; baseline characteristics, prior procedures, and clinical events of interest were captured during the 12-month pre-index (baseline) period. Patients were followed for clinical outcomes (EGV- or bleeding-related emergency room [ER] visits or hospitalization) during the 6-month post-index period. Logistic regression was conducted to identify key predictors of post-index EGV- or bleeding-related ER visit or hospitalization.

Results: 904 patients with aHCC were included in the study (mean age: 61.3 years; 75.3% male). Sorafenib (423 patients, 46.8%) was the most prescribed aHCC treatment. During the entire study period, 458 patients (50.7%) underwent an esophagogastroduodenoscopy (EGD), of whom 209 (45.6%) had post-index EGV. Among 327 patients (36.2%) with a baseline EGD, 175 (53.5%) were diagnosed with EGV and 50 (15.3%) had variceal bleeding; 141 patients (15.6% of all patients) experienced ≥1 EGV- or bleeding-related ER visit or hospitalization post-index.

Conclusion: There is a high prevalence of EGV in patients with aHCC. The presence of EGV, gastrointestinal bleeding, and portal hypertension-related comorbidities was associated with an increased risk of subsequent EGV- or bleeding-related ER visits or hospitalizations in patients with aHCC. Assessment and stratification of varices should be considered in patients with aHCC before initiating systemic therapies to inform treatment decisions.

美国晚期肝细胞癌患者食管胃静脉曲张、出血、急诊就诊和住院的真实患病率:一项回顾性队列研究
目的:食管胃静脉曲张(EGV)和上消化道出血是晚期肝细胞癌(aHCC)患者常见且可能致命的并发症。我们的目的是评估EGV在美国aHCC人群中的真实患病率。患者和方法:这项回顾性队列研究使用了IQVIA的PharMetrics Plus健康计划索赔数据库,时间为2016年1月1日至2021年7月31日(研究期间)。诊断为aHCC并开始全身治疗的成年患者被纳入,而基线时有任何继发性恶性肿瘤或既往肝移植的患者被排除在外。治疗起始日期为指标日期;基线特征、既往程序和感兴趣的临床事件在12个月的指数前(基线)期间被捕获。随访患者6个月的临床结果(EGV或出血相关的急诊室就诊或住院)。进行Logistic回归以确定指数后EGV或出血相关急诊就诊或住院的关键预测因素。结果:904例aHCC患者纳入研究(平均年龄:61.3岁;75.3%的男性)。索拉非尼(423例,46.8%)是最常用的aHCC治疗方案。在整个研究期间,458例(50.7%)患者接受了食管胃十二指肠镜检查(EGD),其中209例(45.6%)患者出现了指数后EGV。在327例基线EGD患者(36.2%)中,175例(53.5%)诊断为EGV, 50例(15.3%)诊断为静脉曲张出血;141例患者(占所有患者的15.6%)经历了≥1次EGV或出血相关的急诊或指数后住院。结论:EGV在aHCC患者中有较高的患病率。在aHCC患者中,EGV、胃肠道出血和门脉高压相关合并症的存在与随后EGV或出血相关急诊就诊或住院的风险增加相关。aHCC患者在开始全身治疗前,应考虑静脉曲张的评估和分层,以便为治疗决策提供信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
0.50
自引率
2.40%
发文量
108
审稿时长
16 weeks
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