Tooth Loss and 12-Year Mortality Risk in 8494 Older Adults From Ireland

IF 4.5 2区医学 Q1 GERIATRICS & GERONTOLOGY

Journal of the American Geriatrics Society Pub Date : 2025-05-19 DOI:10.1111/jgs.19539

Lewis Winning, Siobhan Scarlett, Mark Ward, Michael Crowe, Rose Anne Kenny, Brian O'Connell

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引用次数: 0

Abstract

Objectives

To investigate whether tooth loss is associated with all-cause and cause-specific mortality in older Irish adults.

Methods

A total of 8494 participants from The Irish Longitudinal Study on Ageing (TILDA) were included. Survey data were linked to death registration records, covering individuals who participated in TILDA Wave 1 (2009/2010) and died by 31st January 2022. Cox proportional hazards regressions and competing risk survival analyses were employed to examine the longitudinal relationship between tooth loss and both all-cause and cause-specific mortality.

Results

The mean age of participants at baseline was 63.2 years (SD 10.2). Among the cohort, 3951 (46.5%) were categorized as “Dentate, no denture,” 3041 (35.8%) as “Dentate, with denture(s),” and 1502 (17.7%) as “Edentulous.” Over a median follow-up of 12 years, 1430 (16.8%) participants died. After adjusting for confounders, edentulous participants had a significantly higher hazard ratio (HR) for all-cause mortality compared to dentate participants with no dentures (HR = 1.42, 95% CI 1.23–1.65, p < 0.001). For cause-specific mortality, edentulism had the greatest sub-distribution hazard ratio (SHR) with respiratory mortality (SHR = 1.57, 95% CI 1.03–2.41, p = 0.04), followed by cancer mortality (SHR = 1.31, 95% CI 1.01–1.71, p = 0.04). There was a nonsignificant association with cardiovascular mortality (SHR = 1.25, 95% CI 0.96–1.63, p = 0.10).

Conclusions

Edentulism was independently associated with all-cause mortality in a cohort of 8494 men and women from Ireland. Edentulism was significantly associated with respiratory and cancer mortality.

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8494名爱尔兰老年人牙齿脱落和12年死亡风险

目的：调查牙齿脱落是否与爱尔兰老年人的全因死亡率和病因特异性死亡率有关。方法：共纳入8494名来自爱尔兰老龄化纵向研究（TILDA）的参与者。调查数据与死亡登记记录相关联，涉及参与TILDA第1波（2009/2010年）并于2022年1月31日死亡的个人。采用Cox比例风险回归和竞争风险生存分析来检验牙齿脱落与全因和特定原因死亡率之间的纵向关系。结果：基线时参与者的平均年龄为63.2岁（SD 10.2）。在队列中，3951人（46.5%）被归类为“有齿，无义齿”，3041人（35.8%）被归类为“有齿，有义齿”，1502人（17.7%）被归类为“无齿”。在中位随访12年期间，1430名（16.8%）参与者死亡。在调整混杂因素后，与没有假牙的有牙参与者相比，无牙参与者的全因死亡率风险比（HR）显著更高（HR = 1.42, 95% CI 1.23-1.65, p）。结论：在爱尔兰8494名男性和女性队列中，无牙与全因死亡率独立相关。龋齿症与呼吸系统和癌症死亡率显著相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the American Geriatrics Society 医学-老年医学

CiteScore

10.00

自引率

6.30%

发文量

504

审稿时长

3-6 weeks

期刊介绍： Journal of the American Geriatrics Society (JAGS) is the go-to journal for clinical aging research. We provide a diverse, interprofessional community of healthcare professionals with the latest insights on geriatrics education, clinical practice, and public policy—all supporting the high-quality, person-centered care essential to our well-being as we age. Since the publication of our first edition in 1953, JAGS has remained one of the oldest and most impactful journals dedicated exclusively to gerontology and geriatrics.