Increased risk of colorectal adenoma and benign colorectal polyp associated with Helicobacter pylori infection: a systematic review and meta-analysis.

IF 1.5 4区医学 Q4 ONCOLOGY

Translational cancer research Pub Date : 2025-04-30 Epub Date: 2025-04-07 DOI:10.21037/tcr-24-795

Ju Hee Kim, Hyun Wook Han, Joo Hye Song, Seong-Jang Kim, Young Kook Kim, Hye Jun Kim, Taeho Greg Rhee, Sung Ryul Shim

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引用次数: 0

Abstract

Background: Although the association between Helicobacter pylori (H. pylori) infection and the risk of colorectal adenomas (CRAs) is suggested, specific analysis of the histological subtype of CRA is limited. The aim of the study was to conduct a meta-analysis on the risk of histological classifications of CRA as benign colorectal polyp (BCP), CRA, and advanced CRA to investigate the effects of H. pylori.

Methods: A comprehensive literature searches of the PubMed, Embase, and Cochrane databases through January 2024. Meta-regression analysis was conducted to identify potential moderators (e.g., histological subtype and ethnic groups).

Results: Among the 503,365 participants across 40 studies, H. pylori was consistently associated with increased probabilities of BCP, CRA, and advanced CRA. In BCP, H. pylori positive was found to be associated with an increase [odds ratio (OR), 1.430; 95% confidence interval (CI): 1.292-1.583]. In CRA and advanced CRA, H. pylori positive was found to be associated with an increase (OR, 1.711; 95% CI: 1.408-2.080). In subgroup analysis by ethnicity, Western group had lower OR compared to Asian, with a statistically significant difference observed (Western OR, 1.369; 95% CI: 1.222-1.535 vs. Asian OR, 1.990; 95% CI: 1.416-2.796, P=0.04).

Conclusions: This systematic review and meta-analysis findings revealed a significant association between H. pylori infection and BCP, CRA, and advanced CRA. In particular, meta-regression analysis confirmed that ethnicity acts as a risk factor in both BCP and CRA.

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与幽门螺杆菌感染相关的结直肠腺瘤和良性结直肠息肉风险增加：一项系统综述和荟萃分析。

背景：虽然幽门螺杆菌（Helicobacter pylori， H. pylori）感染与结直肠腺瘤（colorectal adenomas， CRA）发生风险之间存在关联，但对CRA的组织学亚型的具体分析还很有限。本研究的目的是对CRA的组织学分类为良性结肠息肉（BCP）、CRA和晚期CRA的风险进行meta分析，以探讨幽门螺杆菌对CRA的影响。方法：综合检索PubMed、Embase和Cochrane数据库至2024年1月的文献。进行meta回归分析以确定潜在的调节因素（如组织学亚型和种族群体）。结果：在40项研究的503365名参与者中，幽门螺杆菌与BCP、CRA和晚期CRA的概率增加一致相关。在BCP中，幽门螺杆菌阳性与发病率增加相关[比值比（OR）， 1.430；95%置信区间（CI）： 1.292-1.583]。在CRA和晚期CRA中，幽门螺杆菌阳性与发病率升高相关(OR, 1.711；95% ci: 1.408-2.080)。在种族亚组分析中，西方组的OR低于亚洲组，差异有统计学意义(西方OR， 1.369；95% CI: 1.222-1.535，亚洲OR为1.990；95% ci: 1.416-2.796, p =0.04)。结论：本系统综述和荟萃分析结果显示幽门螺杆菌感染与BCP、CRA和晚期CRA之间存在显著关联。特别是，meta回归分析证实，种族是BCP和CRA的一个危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Translational cancer research ONCOLOGY-

CiteScore

2.10

自引率

0.00%

发文量

252

期刊介绍： Translational Cancer Research (Transl Cancer Res TCR; Print ISSN: 2218-676X; Online ISSN 2219-6803; http://tcr.amegroups.com/) is an Open Access, peer-reviewed journal, indexed in Science Citation Index Expanded (SCIE). TCR publishes laboratory studies of novel therapeutic interventions as well as clinical trials which evaluate new treatment paradigms for cancer; results of novel research investigations which bridge the laboratory and clinical settings including risk assessment, cellular and molecular characterization, prevention, detection, diagnosis and treatment of human cancers with the overall goal of improving the clinical care of cancer patients. The focus of TCR is original, peer-reviewed, science-based research that successfully advances clinical medicine toward the goal of improving patients'' quality of life. The editors and an international advisory group of scientists and clinician-scientists as well as other experts will hold TCR articles to the high-quality standards. We accept Original Articles as well as Review Articles, Editorials and Brief Articles.