One Health study of mobile colistin resistance (mcr) in Salmonella enterica in Canada, 2017-2022.

IF 3.7 2区生物学 Q2 MICROBIOLOGY

Microbiology spectrum Pub Date : 2025-05-19 DOI:10.1128/spectrum.02156-24

Ketna Mistry, David Thumbi, Xiao Rui Li, Audrey Charlebois, Brent P Avery, Anne E Deckert, Ashley C Cormier, Colleen Murphy, Ashley Kearney, Jennifer Campbell, Sara Christianson, David C Alexander, Sameh El Bailey, Sadjia Bekal, Linda Chui, Xiaofeng Ding, Tanis Dingle, David Haldane, Linda Hoang, Jessica Minion, Samir Patel, George Zahariadis, Celine Nadon, Michael R Mulvey, Carolee A Carson, Richard J Reid-Smith, Amrita Bharat

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引用次数: 0

Abstract

Colistin is a last-resort treatment for highly drug-resistant bacterial infections. Of 47,184 Salmonella isolates collected from 2017 to 2022 in Canada from human and animal/food sources, mobile colistin resistance (mcr) variants conferring colistin resistance were detected exclusively in humans (n = 15). These variants were mcr-1.1 (n = 7), mcr-3.1 (n = 5), mcr-3.2 (n = 2), and mcr-1.2 (n = 1). The most common mcr-containing serotypes were I 4,[5],12:i:- (n = 8) and Typhimurium (n = 3). The proportion of Salmonella carrying mcr genes remains low in Canada (0.03%).

Importance: Colistin can be used in combination with other drugs as salvage therapy for extensively drug-resistant infections. If mobile colistin resistance (mcr) becomes widely disseminated in Enterobacterales, colistin will no longer be an option for salvage therapy in otherwise untreatable infections. While colistin is not commonly used to treat human Salmonella infections, Salmonella represents an important reservoir of mcr genes that may be transmitted to other gram-negative bacteria. Our aim was to determine the occurrence of mcr genes in Salmonella isolates collected from humans, food animals, and retail meats in Canada.

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2017-2022年加拿大肠炎沙门氏菌移动粘菌素耐药性（mcr）的一项健康研究。

粘菌素是治疗高度耐药细菌感染的最后手段。2017年至2022年在加拿大从人类和动物/食物来源收集的47184株沙门氏菌分离物中，仅在人类中检测到导致粘菌素耐药的移动粘菌素耐药性（mcr）变异（n = 15）。这些变异为mcr-1.1 （n = 7）、mcr-3.1 （n = 5）、mcr-3.2 （n = 2）和mcr-1.2 （n = 1）。最常见的含mcr血清型为i4、[5]、12.i:- (n = 8)和鼠伤寒（n = 3）。携带mcr基因的沙门氏菌在加拿大的比例仍然很低（0.03%）。重要性：粘菌素可与其他药物联合使用，作为广泛耐药感染的救助治疗。如果移动粘菌素耐药性（mcr）在肠杆菌中广泛传播，粘菌素将不再是治疗无法治愈感染的补救性治疗的选择。虽然粘菌素通常不用于治疗人类沙门氏菌感染，但沙门氏菌是mcr基因的重要储存库，可能会传播给其他革兰氏阴性细菌。我们的目的是确定从加拿大的人类、食用动物和零售肉类中收集的沙门氏菌分离株中mcr基因的发生率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microbiology spectrum Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.20

自引率

5.40%

发文量

1800

期刊介绍： Microbiology Spectrum publishes commissioned review articles on topics in microbiology representing ten content areas: Archaea; Food Microbiology; Bacterial Genetics, Cell Biology, and Physiology; Clinical Microbiology; Environmental Microbiology and Ecology; Eukaryotic Microbes; Genomics, Computational, and Synthetic Microbiology; Immunology; Pathogenesis; and Virology. Reviews are interrelated, with each review linking to other related content. A large board of Microbiology Spectrum editors aids in the development of topics for potential reviews and in the identification of an editor, or editors, who shepherd each collection.