A brief report on the association of preoperative hematological indices and acute deep vein thrombosis following total hip arthroplasty for osteoarthritis.
Razvan Marian Melinte, Matei Florin Negrut, Daniel Oltean-Dan, Adrian Dumitru Ivanescu, Tudor-Mihai Magdas, Oana Antal, Adela Hilda Onutu, Marian Andrei Melinte, Robert Bolcas
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引用次数: 0
Abstract
Introduction: Total hip arthroplasty (THA) is a standard orthopedic procedure. Deep vein thrombosis (DVT) and pulmonary embolism are potential life-threatening postoperative complications.
Aim of the study: This study aimed to assess the prognostic value of systemic inflammatory indices [monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio (NLR), platelets-to-lymphocyte ratio (PLR), systemic inflammatory index (SII), systemic inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI)] and their potential association with acute postoperative DVT.
Materials and methods: We designed a multicentric, retrospective, observational cohort study, including adult patients undergoing elective HTA. Patients were divided into two groups, the DVT and non-DVT groups. We investigated the development of acute DVT early, and at 4 weeks after surgery and also registered length of hospital stay and mortality. All demographic data and laboratory data, hematological indices were extracted from patients files.
Results: 199 patients were included. Of those, 12 (6.03%) developed DVT and 187 (93.97%) did not. There was no statistically significant difference between patient age, gender, BMI, smoking status or comorbidities. No difference was founds between the two groups regarding median values of MLR (0.31 vs 0.27, p=0.12), NLR (3.16 vs 2.42, p=0.27), PLR (163.39 vs 123.01, p=0.27), SII (660.26 vs 568.52, p=0.33), SIRI (67.5 vs 65.26, p=0.89) and AISI (302.35 vs 290.48, p=0.85). Length of hospital stay was not significantly different (median 9 days in the DVT group vs 7 days in the non-DVT group, p=0.38), but mortality was significantly higher in the DVT group (3 deaths vs none in the non-DVT group, p<0.001).
Conclusion: MLR, NLR, PRL, SII, SIRI and AISI were not associated with the development of acute DVT following HTA in our study population.
全髋关节置换术（THA）是一种标准的骨科手术。深静脉血栓和肺栓塞是潜在的危及生命的术后并发症。研究目的：本研究旨在评估全身炎症指数[单核细胞与淋巴细胞比值（MLR）、中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、全身炎症指数（SII）、全身炎症反应指数（SIRI）和全身炎症总指数（AISI）]的预后价值及其与急性术后DVT的潜在关联。材料和方法：我们设计了一项多中心、回顾性、观察性队列研究，包括接受选择性HTA治疗的成年患者。患者分为深静脉血栓形成组和非深静脉血栓形成组。我们调查了急性深静脉血栓的早期和术后4周的发展情况，并记录了住院时间和死亡率。所有人口统计资料、实验室数据、血液学指标均从患者档案中提取。结果：纳入199例患者。其中12例（6.03%）发生DVT， 187例（93.97%）未发生DVT。患者年龄、性别、BMI、吸烟状况或合并症之间无统计学差异。两组间MLR （0.31 vs 0.27, p=0.12）、NLR （3.16 vs 2.42, p=0.27）、PLR （163.39 vs 123.01, p=0.27）、SII （660.26 vs 568.52, p=0.33）、SIRI （67.5 vs 65.26, p=0.89）和AISI （302.35 vs 290.48, p=0.85）的中位数均无差异。住院时间无显著差异（DVT组中位数为9天，非DVT组中位数为7天，p=0.38），但DVT组的死亡率显著高于DVT组(3例死亡，非DVT组无死亡，p结论：在我们的研究人群中，MLR、NLR、PRL、SII、SIRI和AISI与HTA后急性DVT的发生无关。
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