Impact of the choice of biomarkers and equations to estimate kidney function on the epidemiology of chronic kidney disease.

IF 2.2 3区医学 Q3 PERIPHERAL VASCULAR DISEASE

Current Opinion in Nephrology and Hypertension Pub Date : 2025-07-01 Epub Date: 2025-05-16 DOI:10.1097/MNH.0000000000001085

Pierre Delanaye, Rouvick Mariano Gama, Thomas Stehlé

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引用次数: 0

Abstract

Purpose of review: The CKD-EPI equations were updated in 2021 to remove the race variable from eGFR estimation. In the same year, the creatinine-based EKFC equation was published, subsequently supplemented by the cystatin C-based EKFC equation. Recent findings suggest that the prevalence of chronic kidney disease (CKD) can vary depending on the equation, the biomarker, and the population studied.

Recent findings: Using the CKD-EPI 2021 equation instead of the CKD-EPI 2009 equation results in an increased prevalence of CKD among Black individuals in the U.S. and a decreased prevalence among non-Blacks. The CKD-EPI equations may underestimate the prevalence of CKD in India and in some sub-Saharan African populations. This is corrected by using the EKFC equation and dedicated Q-values. In general, the prevalence of CKD is slightly higher with EKFC than with the CKD-EPI equations. The CKD-EPI cys equation generally leads to a higher CKD prevalence than the CKD-EPIcrea equations. Few epidemiological data are available for EKFC cys .

Summary: The choice of biomarkers and equations has an impact on the prevalence of CKD, with implications that also depend on the characteristics of the population being studied.

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选择生物标志物和方程来评估肾功能对慢性肾脏疾病流行病学的影响。

回顾目的：2021年更新了CKD-EPI方程，以从eGFR估计中删除种族变量。同年，发表了基于肌酐的EKFC方程，随后补充了基于胱抑素c的EKFC方程。最近的研究结果表明，慢性肾脏疾病（CKD）的患病率可能因方程、生物标志物和研究人群而异。最近的发现：使用CKD- epi2021方程代替CKD- epi2009方程导致美国黑人CKD患病率增加，非黑人患病率降低。CKD- epi方程可能低估了CKD在印度和一些撒哈拉以南非洲人口中的患病率。这可以通过使用EKFC方程和专用q值来纠正。一般来说，EKFC的CKD患病率略高于CKD- epi方程。CKD- epicys方程通常比CKD- epicrea方程导致更高的CKD患病率。很少有关于EKFCcys的流行病学数据。摘要：生物标志物和方程的选择对CKD的患病率有影响，其影响也取决于所研究人群的特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Nephrology and Hypertension 医学-泌尿学与肾脏学

CiteScore

5.70

自引率

6.20%

发文量

132

审稿时长

6-12 weeks

期刊介绍： A reader-friendly resource, Current Opinion in Nephrology and Hypertension provides an up-to-date account of the most important advances in the field of nephrology and hypertension. Each issue contains either two or three sections delivering a diverse and comprehensive coverage of all the key issues, including pathophysiology of hypertension, circulation and hemodynamics, and clinical nephrology. Current Opinion in Nephrology and Hypertension is an indispensable journal for the busy clinician, researcher or student.