Effect of age and day time on the adenosine modulation of basal and insulin-stimulated glucose transport in rat adipocytes.

P Bush, J E Souness, V Chagoya de Sánchez
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引用次数: 5

Abstract

1. The relationship between the activity of adenosine metabolizing enzymes 5'nucleotidase (5'N), adenosine kinase (A.K.) and adenosine deaminase (A.D.) with basal and insulin-stimulated glucose transport in isolated fat cells from young and old animals was studied at 08:00 and 16:00 hr. 2. In cells from young animals a larger insulin-stimulation of glucose transport was observed at 16:00 hr than at 08:00 hr. Also at 16:00 hr small changes in 5'N, A.K. and A.D. activities suggest a decrease in adenosine formation. 3. In the cells from old animals no effect of insulin was observed at any time, while a 3-5-fold increase in 5'N indicated a predominance of adenosine formation at both times studied. 4. An inverse relationship was observed in the changes of adenosine metabolism and insulin action.

年龄和白天时间对腺苷调节基础和胰岛素刺激的大鼠脂肪细胞葡萄糖转运的影响。
1. 在08:00和16:00时,研究了腺苷代谢酶5′核苷酸酶(5n)、腺苷激酶(A.K.)和腺苷脱氨酶(A.D.)活性与基础和胰岛素刺激的离体动物脂肪细胞葡萄糖转运的关系。2. 在幼龄动物细胞中,观察到16:00时胰岛素对葡萄糖转运的刺激大于08:00时。同样在16:00时,5 - n、a.k和ad活性的微小变化表明腺苷形成减少。3.在老年动物的细胞中,胰岛素在任何时候都没有影响,而5- n增加3-5倍表明在研究的两个时间里腺苷的形成都占主导地位。4. 腺苷代谢变化与胰岛素作用呈反比关系。
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